Alterations of neurotransmitters and related metabolites in the habenula from CUMS-susceptible and -resilient rats.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.11.065
Abstract: Although major depressive disorder (MDD) has caused severe mental harm to overwhelming amounts of patients, the pathogenesis of MDD remains to be studied. Due to the in-depth discussion of the mechanism of new antidepressants like… read more here.
Keywords: group; neurotransmitters related; alterations neurotransmitters; resilient rats ... See more keywords
A single-run, rapid polarity switching method for simultaneous quantification of cardiovascular disease-related metabolites using liquid chromatography–tandem mass spectrometry
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Mass Spectrometry"
DOI: 10.1016/j.ijms.2020.116500
Abstract: Abstract Several amino acids, nucleotide metabolites, organic acids, and choline-related metabolites have been identified as possible risk factors for cardiovascular disease (CVD). However, a method that allows rapid processing of a large number of samples… read more here.
Keywords: run; related metabolites; disease; mass spectrometry ... See more keywords
Impact of lincosamides antibiotics on the composition of the rat gut microbiota and the metabolite profile of plasma and feces.
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2018.08.002
Abstract: The importance of the gut microorganisms and their wide range of interactions with the host are well-acknowledged. In this study, lincomycin and clindamycin were used to modulate microbial communities of Wistar rats to gain a… read more here.
Keywords: gut; microbial community; impact lincosamides; related metabolites ... See more keywords
TRIMETHYLAMINE-N-OXIDE AND RELATED METABOLITES ARE ASSOCIATED WITH CARDIOVASCULAR EVENTS: RESULTS FROM THE DALLAS HEART STUDY
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(19)32345-9
Abstract: The human microbiota may contribute to atherosclerotic cardiovascular disease (ASCVD) through the production of trimethylamine-N-oxide (TMAO), a gut microbiota-dependent metabolite previously implicated in atherosclerosis. Prior studies suggest that TMAO levels predict future ASCVD events in… read more here.
Keywords: oxide related; cardiovascular events; associated cardiovascular; related metabolites ... See more keywords
Potential of spectroscopic analyses for non-destructive estimation of tea quality-related metabolites in fresh new leaves
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-83847-0
Abstract: Spectroscopic sensing provides physical and chemical information in a non-destructive and rapid manner. To develop non-destructive estimation methods of tea quality-related metabolites in fresh leaves, we estimated the contents of free amino acids, catechins, and… read more here.
Keywords: quality related; tea quality; non destructive; related metabolites ... See more keywords
Impacts of lipid-related metabolites, adiposity, and genetic background on blood eosinophil counts: the Nagahama study
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-94835-9
Abstract: Blood eosinophil count is a useful measure in asthma or COPD management. Recent epidemiological studies revealed that body mass index (BMI) is positively associated with eosinophil counts. However, few studies focused on the role of… read more here.
Keywords: blood eosinophil; eosinophil counts; genetic background; study ... See more keywords
Identification of novel non-synonymous variants associated with type 2 diabetes-related metabolites in Korean population
Sign Up to like & getrecommendations! Published in 2019 at "Bioscience Reports"
DOI: 10.1042/bsr20190078
Abstract: Abstract Metabolome-genome wide association studies (mGWASs) are useful for understanding the genetic regulation of metabolites in complex diseases, including type 2 diabetes (T2D). Numerous genetic variants associated with T2D-related metabolites have been identified in previous… read more here.
Keywords: variants associated; type diabetes; synonymous variants; related metabolites ... See more keywords
Prioritizing candidate diseases-related metabolites based on literature and functional similarity
Sign Up to like & getrecommendations! Published in 2019 at "BMC Bioinformatics"
DOI: 10.1186/s12859-019-3127-4
Abstract: As the terminal products of cellular regulatory process, functional related metabolites have a close relationship with complex diseases, and are often associated with the same or similar diseases. Therefore, identification of disease related metabolites play… read more here.
Keywords: network; candidate; disease; related metabolites ... See more keywords
Explore potential disease related metabolites based on latent factor model
Sign Up to like & getrecommendations! Published in 2022 at "BMC Genomics"
DOI: 10.1186/s12864-022-08504-w
Abstract: Background In biological systems, metabolomics can not only contribute to the discovery of metabolic signatures for disease diagnosis, but is very helpful to illustrate the underlying molecular disease-causing mechanism. Therefore, identification of disease-related metabolites is… read more here.
Keywords: latent factor; disease related; model; based latent ... See more keywords
Metabolome analysis of genus Forsythia related constituents in Forsythia suspensa leaves and fruits using UPLC-ESI-QQQ-MS/MS technique
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0269915
Abstract: Forsythia suspensa is a traditional Chinese herb. Its numerous metabolites have important roles, as they possessed a wide range of biological activities. This study explored the accumulations of F. suspensa metabolites by performing widely targeted… read more here.
Keywords: forsythia suspensa; forsythia related; leaves fruits; forsythia ... See more keywords
Prediction of Ovarian Cancer-Related Metabolites Based on Graph Neural Network
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.753221
Abstract: Ovarian cancer is one of the three most malignant tumors of the female reproductive system. At present, researchers do not know its pathogenesis, which makes the treatment effect unsatisfactory. Metabolomics is closely related to drug… read more here.
Keywords: network; cancer related; related metabolites; ovarian cancer ... See more keywords