Epidemiologic outlook of therapy‐related myeloid neoplasms and selection of high‐risk patients: A Korean nationwide study
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DOI: 10.1002/cncr.34453
Abstract: Although a considerable proportion of patients with cancer receive chemotherapy (CT) or radiotherapy (RT), only a very few patients eventually develop therapy‐related myeloid neoplasms (t‐MNs). read more here.
Keywords: related myeloid; outlook therapy; myeloid neoplasms; therapy related ... See more keywords
Therapy-related myeloid neoplasms with different latencies: a detailed clinicopathologic analysis
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DOI: 10.1038/s41379-021-00958-9
Abstract: Therapy-related myeloid neoplasm (t-MN) arising in patients with prior cytotoxic treatments is considered a distinct entity due to its unfavorable prognosis. Latencies between the initial cytotoxic therapy and the occurrence of t-MNs vary but usually… read more here.
Keywords: myeloid neoplasms; therapy related; mns ordinary; therapy ... See more keywords
Clonal evolution in patients developing therapy-related myeloid neoplasms following autologous stem cell transplantation
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DOI: 10.1038/s41409-022-01567-z
Abstract: Clonal hematopoiesis (CH) denotes somatic mutations in genes related to myeloid neoplasms present at any variant allele frequency (VAF). Clonal hematopoiesis is associated with increasing age and with a factor 6 increase in the risk… read more here.
Keywords: therapy related; tmn; related myeloid; myeloid neoplasms ... See more keywords
Updates in molecular genetics of therapy-related myeloid neoplasms.
Sign Up to like & getrecommendations! Published in 2023 at "Seminars in diagnostic pathology"
DOI: 10.1053/j.semdp.2023.04.001
Abstract: Therapy-related myeloid neoplasms (t-MN) are a heterogeneous group of aggressive myeloid neoplasms that arise following exposure to various cytotoxic therapeutic agents and/or ionizing radiation for treatment of prior non-myeloid malignancy or autoimmune disease. Each therapeutic… read more here.
Keywords: updates molecular; related myeloid; myeloid neoplasms; therapy related ... See more keywords
Therapy-related myeloid neoplasms
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DOI: 10.1097/moh.0000000000000316
Abstract: Purpose of review Advances in the genetic characterization of patients with therapy-related myeloid neoplasms (t-MNs) have changed our understanding of the pathogenesis of these diseases. In addition, extensive sequencing studies have identified recurrent mutations with… read more here.
Keywords: myeloid neoplasms; therapy related; related myeloid; risk ... See more keywords
Clonal haematopoiesis as a risk factor for therapy‐related myeloid neoplasms in patients with chronic lymphocytic leukaemia treated with chemo‐(immuno)therapy
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Haematology"
DOI: 10.1111/bjh.18129
Abstract: Clonal haematopoiesis of indeterminate potential (CHIP) may predispose for the development of therapy‐related myeloid neoplasms (t‐MN). Using target next‐generation sequencing (t‐NGS) panels and digital droplet polymerase chain reactions (ddPCR), we studied the myeloid gene mutation… read more here.
Keywords: related myeloid; therapy; clonal haematopoiesis; therapy related ... See more keywords
Therapy‐related myeloid neoplasms with normal karyotype show distinct genomic and clinical characteristics compared to their counterparts with abnormal karyotype
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Haematology"
DOI: 10.1111/bjh.18154
Abstract: Therapy‐related myeloid neoplasms (t‐MNs) are a complication of treatment with cytotoxic chemotherapy and/or radiation therapy. The majority of t‐MNs show chromosomal abnormalities associated with myelodysplastic syndrome (MDS) or KMT2A rearrangements and are characterized by poor… read more here.
Keywords: normal karyotype; related myeloid; mns; therapy ... See more keywords
Lenalidomide promotes the development of TP53-mutated therapy-related myeloid neoplasms
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DOI: 10.1182/blood.2021014956
Abstract: Abstract There is a growing body of evidence that therapy-related myeloid neoplasms (t-MNs) with driver gene mutations arise in the background of clonal hematopoiesis (CH) under the positive selective pressure of chemo- and radiation therapies.… read more here.
Keywords: related myeloid; myeloid neoplasms; therapy related; treatment ... See more keywords
Genomics of therapy-related myeloid neoplasms
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DOI: 10.3324/haematol.2019.219352
Abstract: Heterogeneity of treatment related myeloid neoplasms (tMN) might be partially related to inadvertent inclusion of coincidental second disease and neoplasia due to genetic predisposition. Clinical features or traditional morphology and cytogenetics are not sufficiently distinctive… read more here.
Keywords: myeloid neoplasms; related myeloid; genomics therapy; therapy related ... See more keywords