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Published in 2020 at "Neurotherapeutics"
DOI: 10.1007/s13311-020-00853-2
Abstract: Neurological disorders such as Alzheimer’s disease (AD), Lewy body dementia (LBD), frontotemporal dementia (FTD), and vascular dementia (VCID) have no disease-modifying treatments to date and now constitute a dementia crisis that affects 5 million in…
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Keywords:
protein;
related neurodegenerative;
disease;
neurodegenerative diseases ... See more keywords
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Published in 2020 at "Aging Clinical and Experimental Research"
DOI: 10.1007/s40520-020-01485-4
Abstract: Alzheimer and Parkinson’s diseases are neurodegenerative aging-related pathological conditions, mainly caused by the interplay of genetic and non-genetic factors and whose incidence rate is going to drastically increase given the growing life expectancy. To address…
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Keywords:
cnvs common;
related neurodegenerative;
aging related;
common aging ... See more keywords
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Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2016.10.490
Abstract: Abstract Oxidative stress is involved in various and numerous pathological states including several age‐related neurodegenerative diseases. Peroxidation of the membrane lipid bilayer is one of the major sources of free radical‐mediated injury that directly damages…
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Keywords:
age related;
related neurodegenerative;
disease;
brain ... See more keywords
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Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119343
Abstract: Aging is a risk factor for major central nervous system (CNS) disorders. More specifically, aging can be inked to neurodegenerative diseases (NDs) because of its deteriorating impact on neurovascular unit (NVU). Metformin, a first line…
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Keywords:
ischemic stroke;
related neurodegenerative;
metformin treat;
metformin ... See more keywords
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Published in 2023 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.1100133
Abstract: Microglia, characterized by responding to damage, regulating the secretion of soluble inflammatory mediators, and engulfing specific segments in the central nervous system (CNS), function as key immune cells in the CNS. Emerging evidence suggests that…
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Keywords:
role;
related neurodegenerative;
microglia autophagy;
age related ... See more keywords
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Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.844193
Abstract: Aging-related neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS), are gradually becoming the primary burden of society and cause significant health-care concerns. Aging is a critical…
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Keywords:
roles long;
related neurodegenerative;
development aging;
aging related ... See more keywords
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Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11041154
Abstract: Traumatic brain injury (TBI) survivors frequently suffer from chronically progressive complications, including significantly increased risk of developing aging-related neurodegenerative disease. As advances in neurocritical care increase the number of TBI survivors, the impact and awareness…
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Keywords:
related neurodegenerative;
disease;
brain;
risk ... See more keywords
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Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20143518
Abstract: 14-3-3 proteins are a family of conserved regulatory adaptor molecules which are expressed in all eukaryotic cells. These proteins participate in a variety of intracellular processes by recognizing specific phosphorylation motifs and interacting with hundreds…
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Keywords:
cancer aging;
age related;
aging age;
related neurodegenerative ... See more keywords