Immunotherapies for Aging-Related Neurodegenerative Diseases—Emerging Perspectives and New Targets
Sign Up to like & getrecommendations! Published in 2020 at "Neurotherapeutics"
DOI: 10.1007/s13311-020-00853-2
Abstract: Neurological disorders such as Alzheimer’s disease (AD), Lewy body dementia (LBD), frontotemporal dementia (FTD), and vascular dementia (VCID) have no disease-modifying treatments to date and now constitute a dementia crisis that affects 5 million in… read more here.
Keywords: protein; related neurodegenerative; disease; neurodegenerative diseases ... See more keywords
The contribution of CNVs to the most common aging-related neurodegenerative diseases
Sign Up to like & getrecommendations! Published in 2020 at "Aging Clinical and Experimental Research"
DOI: 10.1007/s40520-020-01485-4
Abstract: Alzheimer and Parkinson’s diseases are neurodegenerative aging-related pathological conditions, mainly caused by the interplay of genetic and non-genetic factors and whose incidence rate is going to drastically increase given the growing life expectancy. To address… read more here.
Keywords: cnvs common; related neurodegenerative; aging related; common aging ... See more keywords
Role of 4‐hydroxy‐2‐nonenal (HNE) in the pathogenesis of alzheimer disease and other selected age‐related neurodegenerative disorders
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2016.10.490
Abstract: Abstract Oxidative stress is involved in various and numerous pathological states including several age‐related neurodegenerative diseases. Peroxidation of the membrane lipid bilayer is one of the major sources of free radical‐mediated injury that directly damages… read more here.
Keywords: age related; related neurodegenerative; disease; brain ... See more keywords
Repurposing metformin to treat age-related neurodegenerative disorders and ischemic stroke.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119343
Abstract: Aging is a risk factor for major central nervous system (CNS) disorders. More specifically, aging can be inked to neurodegenerative diseases (NDs) because of its deteriorating impact on neurovascular unit (NVU). Metformin, a first line… read more here.
Keywords: ischemic stroke; related neurodegenerative; metformin treat; metformin ... See more keywords
Serine Palmitoyltransferase (SPT)-related Neurodegenerative and Neurodevelopmental Disorders
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Neuromuscular Diseases"
DOI: 10.3233/jnd-240014
Abstract: Motor neuron diseases and peripheral neuropathies are heterogeneous groups of neurodegenerative disorders that manifest with distinct symptoms due to progressive dysfunction or loss of specific neuronal subpopulations during different stages of development. A few monogenic,… read more here.
Keywords: spt related; palmitoyltransferase; serine palmitoyltransferase; related neurodegenerative ... See more keywords
Role of microglia autophagy and mitophagy in age-related neurodegenerative diseases
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.1100133
Abstract: Microglia, characterized by responding to damage, regulating the secretion of soluble inflammatory mediators, and engulfing specific segments in the central nervous system (CNS), function as key immune cells in the CNS. Emerging evidence suggests that… read more here.
Keywords: role; related neurodegenerative; microglia autophagy; age related ... See more keywords
Roles of Long Non-coding RNAs in the Development of Aging-Related Neurodegenerative Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.844193
Abstract: Aging-related neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS), are gradually becoming the primary burden of society and cause significant health-care concerns. Aging is a critical… read more here.
Keywords: roles long; related neurodegenerative; development aging; aging related ... See more keywords
Neuroinflammation in Age-Related Neurodegenerative Diseases: Role of Mitochondrial Oxidative Stress
Sign Up to like & getrecommendations! Published in 2024 at "Antioxidants"
DOI: 10.3390/antiox13121440
Abstract: A shared hallmark of age-related neurodegenerative diseases is the chronic activation of innate immune cells, which actively contributes to the neurodegenerative process. In Alzheimer’s disease, this inflammatory milieu exacerbates both amyloid and tau pathology. A… read more here.
Keywords: role; inflammatory; age related; neurodegenerative diseases ... See more keywords
Increased Risk of Aging-Related Neurodegenerative Disease after Traumatic Brain Injury
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11041154
Abstract: Traumatic brain injury (TBI) survivors frequently suffer from chronically progressive complications, including significantly increased risk of developing aging-related neurodegenerative disease. As advances in neurocritical care increase the number of TBI survivors, the impact and awareness… read more here.
Keywords: related neurodegenerative; disease; brain; risk ... See more keywords
14-3-3 Proteins Are on the Crossroads of Cancer, Aging, and Age-Related Neurodegenerative Disease
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20143518
Abstract: 14-3-3 proteins are a family of conserved regulatory adaptor molecules which are expressed in all eukaryotic cells. These proteins participate in a variety of intracellular processes by recognizing specific phosphorylation motifs and interacting with hundreds… read more here.
Keywords: cancer aging; age related; aging age; related neurodegenerative ... See more keywords
The Therapeutic Potential of Dietary Phytochemicals in Age-Related Neurodegenerative Disorders
Sign Up to like & getrecommendations! Published in 2025 at "Pharmaceuticals"
DOI: 10.3390/ph18091268
Abstract: In recent times, neurodegenerative diseases have become a global health concern, particularly among the elderly. This may be attributed to the increased risk of neuronal death due to age. Moreover, the underlying mechanisms of neurodegeneration… read more here.
Keywords: age; age related; dietary phytochemicals; neurodegenerative disorders ... See more keywords