Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer‐related pathways in breast cancer
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.1938
Abstract: Protein Kinase D (PKD) family contains PKD1, PKD2, and PKD3 in human. Compared to consistent tumor‐suppressive functions of PKD1 in breast cancer, how PKD2/3 functions in breast cancer are not fully understood. In the current… read more here.
Keywords: cancer related; breast cancer; protein kinase; cancer ... See more keywords
The understudied links of the retromer complex to age-related pathways.
Sign Up to like & getrecommendations! Published in 2021 at "GeroScience"
DOI: 10.1007/s11357-021-00430-1
Abstract: Neuronal aging is associated with numerous diseases resulting in memory impairment and functional decline. A common hallmark of these disorders is the accumulation of intracellular and extracellular protein aggregates. The retromer complex plays a central… read more here.
Keywords: age related; links retromer; age; retromer complex ... See more keywords
Identification of transcriptomic signatures and crucial pathways involved in non-alcoholic steatohepatitis
Sign Up to like & getrecommendations! Published in 2021 at "Endocrine"
DOI: 10.1007/s12020-021-02716-y
Abstract: Our study aimed to uncover the crucial genes and functional pathways involved in the development of non-alcoholic steatohepatitis (NASH). Liver transcriptome datasets were integrated with Robust rank aggregation (RRA) method, and transcriptomic signatures for NASH… read more here.
Keywords: fibrosis; non alcoholic; alcoholic steatohepatitis; transcriptomic signatures ... See more keywords
Identification of miRNAs and their potential effects on multiple sclerosis related pathways using ın silico analysis.
Sign Up to like & getrecommendations! Published in 2022 at "Multiple sclerosis and related disorders"
DOI: 10.1016/j.msard.2022.103642
Abstract: BACKGROUND MicroRNAs (miRNAs) regulate gene expression post-transcriptionally via mRNA degradation. As a result, they have an impact on a variety of pathways in organisms that are important for both health and disease. miRNAs can be… read more here.
Keywords: analysis; related pathways; mirnas potential; sclerosis related ... See more keywords
Improved redox homeostasis owing to the up-regulation of one-carbon metabolism and related pathways is crucial for yeast heterosis at high temperature.
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DOI: 10.1101/gr.262055.120
Abstract: Heterosis or hybrid vigor is a common phenomenon in plants and animals; however, the molecular mechanisms underlying heterosis remain elusive, despite extensive studies on the phenomenon for more than a century. Here we constructed a… read more here.
Keywords: homeostasis; metabolism related; heterosis; one carbon ... See more keywords
Relevance of NLRP3 Inflammasome-Related Pathways in the Pathology of Diabetic Wound Healing and Possible Therapeutic Targets
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/9687925
Abstract: Wound healing is a major secondary complication in type 2 diabetes, which results in significant disability and mortality, imposing a significant clinical and social burden. Sustained activation of the Nod-like receptor protein (NLRP) inflammasome in… read more here.
Keywords: related pathways; inflammasome related; wound healing; inflammasome ... See more keywords
Abstract 548: The effects of Sirtuin 6 inhibition on autophagy-related pathways in melanoma
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DOI: 10.1158/1538-7445.am2018-548
Abstract: Melanoma is an aggressive skin cancer that can rapidly metastasize to become fatal, if not diagnosed early. Despite therapeutic advances, clinical management of melanoma remains challenging. The existing chemotherapeutic drugs either fail to achieve greater… read more here.
Keywords: melanoma; melanoma cells; autophagy related; cancer ... See more keywords
Effect of sex chromosomes versus hormones in neonatal lung injury
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DOI: 10.1172/jci.insight.146863
Abstract: The main mechanisms underlying sexually dimorphic outcomes in neonatal lung injury are unknown. We tested the hypothesis that hormone- or sex chromosome–mediated mechanisms interact with hyperoxia exposure to impact injury and repair in the neonatal… read more here.
Keywords: related pathways; pathways enriched; neonatal lung; sex ... See more keywords
Gene expression patterns and related pathways in the hearts of rhesus monkeys subjected to prolonged myocardial ischemia
Sign Up to like & getrecommendations! Published in 2023 at "Experimental Biology and Medicine"
DOI: 10.1177/15353702231151968
Abstract: After myocardial infarction (MI) occurs, progressive pathological cardiac remodeling results in heart dysfunction and even heart failure during the following months or years. The present study explored the molecular mechanisms underlying the late phase of… read more here.
Keywords: related pathways; area; myocardial ischemia; heart ... See more keywords
Comprehensive analysis of metastatic seminoma germ cell tumors shows divergent expression of immune-related pathways.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.7_suppl.506
Abstract: 506 Background: Not much is known about the molecular mechanisms resulting in tumor progression and finally leading to metastasis in testicular germ cell tumor (TGCT). Only a few studies in some other tumor types have… read more here.
Keywords: expression; related pathways; tumor; germ cell ... See more keywords
Autophagy-Related Pathways in Vesicular Unconventional Protein Secretion
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.892450
Abstract: Cellular proteins directed to the plasma membrane or released into the extracellular space can undergo a number of different pathways. Whereas the molecular mechanisms that underlie conventional ER-to-Golgi trafficking are well established, those associated with… read more here.
Keywords: autophagy related; related pathways; protein secretion; unconventional protein ... See more keywords