Phage Display Selected Cyclic Peptide Inhibitors of Kallikrein-Related Peptidases 5 and 7 and Their In Vivo Delivery to the Skin.
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DOI: 10.1021/acs.jmedchem.2c00306
Abstract: Kallikrein-related peptidases 5 (KLK5) and 7 (KLK7) are serine proteases with homeostatic functions in the epidermis that play a critical role in Netherton syndrome (NS), a rare yet life-threatening genetic disorder that currently lacks specific… read more here.
Keywords: related peptidases; phage display; kallikrein related; peptide ... See more keywords
Human Tissue Kallikreins-Related Peptidases Are Targets for the Treatment of Skin Desquamation Diseases
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DOI: 10.3389/fmed.2021.777619
Abstract: Human tissue Kallikrein-related peptidases (hKLKs) are serine proteases distributed in several tissues that are involved in several biological processes. In skin, many are responsible for skin desquamation in the Stratum Corneum (SC) of the epidermis,… read more here.
Keywords: skin desquamation; skin diseases; desquamation; related peptidases ... See more keywords