The role of microRNAs in diseases and related signaling pathways.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular biology reports"
DOI: 10.1007/s11033-021-06725-y
Abstract: MicroRNAs (miRNAs) are epigenetic regulators of the gene expression and act through posttranslational modification. They bind to 3'-UTR of target mRNAs to inhibit translation or increase the degradation mRNA in many tissues. Any alteration in… read more here.
Keywords: signaling pathways; diseases related; related signaling; role ... See more keywords
Deep Sequencing Reveals the Significant Involvement of cAMP-Related Signaling Pathways Following Sciatic Nerve Crush
Sign Up to like & getrecommendations! Published in 2017 at "Neurochemical Research"
DOI: 10.1007/s11064-017-2409-3
Abstract: Peripheral nerve injury and regeneration is a complex biological process jointly mediated by numerous factors. Cyclic adenosine monophosphate (cAMP) modifies the cellular behaviors of neurons and Schwann cells, and thus may contribute to peripheral nerve… read more here.
Keywords: signaling pathways; camp related; related signaling; nerve ... See more keywords
Oral quetiapine treatment results in time-dependent alterations of recognition memory and brain-derived neurotrophic factor-related signaling molecules in the hippocampus of rats
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacology Biochemistry and Behavior"
DOI: 10.1016/j.pbb.2020.172999
Abstract: Antipsychotic drugs (APDs) have a variety of important therapeutic applications for neuropsychiatric disorders. However, they are routinely prescribed off-label across all age categories, a controversial practice given their potential for producing metabolic and extrapyramidal side… read more here.
Keywords: recognition memory; treatment; related signaling; brain ... See more keywords
The pharmacological perturbation of brain zinc impairs BDNF-related signaling and the cognitive performances of young mice
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-28083-9
Abstract: Zinc (Zn2+) is a pleiotropic modulator of the neuronal and brain activity. The disruption of intraneuronal Zn2+ levels triggers neurotoxic processes and affects neuronal functioning. In this study, we investigated how the pharmacological modulation of… read more here.
Keywords: perturbation brain; bdnf related; brain zn2; related signaling ... See more keywords
Insights from bioinformatics analysis reveal that lipopolysaccharide induces activation of chemokine-related signaling pathways in human nasal epithelial cells
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-58317-y
Abstract: Lipopolysaccharide (LPS) is known to elicit a robust immune response. This study aimed to investigate the impact of LPS on the transcriptome of human nasal epithelial cells (HNEpC). HNEpC were cultured and stimulated with LPS… read more here.
Keywords: chemokine related; human nasal; signaling pathways; related signaling ... See more keywords
Interleukin-6 related signaling pathways as the intersection between chronic diseases and sepsis
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Medicine"
DOI: 10.1186/s10020-025-01089-6
Abstract: Sepsis is associated with immune dysregulated and organ dysfunction due to severe infection. Clinicians aim to restore organ function, rather than prevent diseases that are prone to sepsis, resulting in high mortality and a heavy… read more here.
Keywords: signaling pathways; related signaling; related pathways; chronic diseases ... See more keywords
The node-weighted Steiner tree approach to identify elements of cancer-related signaling pathways
Sign Up to like & getrecommendations! Published in 2017 at "BMC Bioinformatics"
DOI: 10.1186/s12859-017-1958-4
Abstract: BackgroundCancer constitutes a momentous health burden in our society. Critical information on cancer may be hidden in its signaling pathways. However, even though a large amount of money has been spent on cancer research, some… read more here.
Keywords: signaling pathways; related signaling; cancer related; approach ... See more keywords
A proteomics approach for the identification of cullin-9 (CUL9) related signaling pathways in induced pluripotent stem cell models
Sign Up to like & getrecommendations! Published in 2021 at "PLoS ONE"
DOI: 10.1371/journal.pone.0248000
Abstract: CUL9 is a non-canonical and poorly characterized member of the largest family of E3 ubiquitin ligases known as the Cullin RING ligases (CRLs). Most CRLs play a critical role in developmental processes, however, the role… read more here.
Keywords: signaling pathways; cul9 related; cul9; related signaling ... See more keywords
Dysregulation of transfer RNA-derived small RNAs that regulate cell activity and its related signaling pathways in human cancers.
Sign Up to like & getrecommendations! Published in 2023 at "Current gene therapy"
DOI: 10.2174/1566523223666230601102506
Abstract: tsRNAs are small noncoding RNAs that originate from tRNA cleavage and play important regulatory roles in gene expression, translation, transcription, and epigenetic modification. The dysregulation of tsRNAs in cancer disrupts gene expression and perturbs various… read more here.
Keywords: cell activity; cell; dysregulation; signaling pathways ... See more keywords
The mechanisms and diagnostic potential of lncRNAs, miRNAs, and their related signaling pathways in cervical cancer
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1170059
Abstract: Cervical cancer (CC), the fourth most prevalent type of cancer among women worldwide, is associated with high rates of morbidity and mortality. Due to the long period of latency in CC, most patients are already… read more here.
Keywords: cervical cancer; mirnas lncrnas; mechanisms diagnostic; signaling pathways ... See more keywords
Comprehensive Expression Profile Analysis of Neutrophil Extracellular Trap-Affected Genes in Gastric Cancer Cells and the Clinical Significance of lncRNA NEAT1-Related Signaling
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.798531
Abstract: Background Gastric cancer (GC) is the fifth most common malignant tumor and the third leading cause of cancer-related deaths worldwide. Neutrophil extracellular traps (NETs) can enhance the invasion of GC cells and are associated with… read more here.
Keywords: lncrna neat1; clinical significance; expression; related signaling ... See more keywords