Applying green analytical chemistry (GAC) for development of stability indicating HPLC method for determining clonazepam and its related substances in pharmaceutical formulations and calculating uncertainty
Sign Up to like & getrecommendations! Published in 2019 at "Arabian Journal of Chemistry"
DOI: 10.1016/j.arabjc.2014.10.051
Abstract: Abstract Clonazepam contains one benzodiazepine ring in its chemical structure which makes it vulnerable to degradation. In this study, green analytical chemistry approach was applied in attempts for the development of validated stability indicating RP-HPLC… read more here.
Keywords: green analytical; related substances; method; clonazepam ... See more keywords
Identification of related substances in tofacitinib citrate by LC‐MS techniques for synthetic process optimization
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2017.05.012
Abstract: &NA; A specific LC‐MS method was developed for separation, identification and characterization of the process‐related substances and degradation products in tofacitinib citrate. The separation was achieved on a LiChrospher C18 column (250 mm × 4.6… read more here.
Keywords: degradation; process; related substances; identification ... See more keywords
Analysis of bacitracin and its related substances by liquid chromatography tandem mass spectrometry
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical Analysis"
DOI: 10.1016/j.jpha.2016.06.001
Abstract: A suitable liquid chromatography quadrupole time-of-flight mass spectrometric (LC–Q-TOF–MS) method was developed for separation and characterization of related substances in bacitracin test drug. The separation was performed on LiChrospher RP-18 column using methanol as mobile… read more here.
Keywords: analysis bacitracin; related substances; mass; liquid chromatography ... See more keywords
Development of an Analytical Method for Determination of Related Substances and Degradation Products of Cabotegravir Using Analytical Quality by Design Principles
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.1c07260
Abstract: Cabotegravir is one of the newly approved human immunodeficiency virus (HIV) integrase enzyme inhibitors used for the prevention and treatment of HIV infection. It is the first approved long-acting injectable antiretroviral therapy for HIV and… read more here.
Keywords: cabotegravir; development; design; method ... See more keywords
A Novel HPLC Method for Quality Inspection of NRK Biosynthesized β-Nicotinamide Mononucleotide.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chromatographic science"
DOI: 10.1093/chromsci/bmac107
Abstract: β-nicotinamide mononucleotide (NMN) has a good effect on delaying aging, repairing DNA and ameliorating metabolic disease. Biosynthesis with nicotinamide riboside kinase (NRK) takes a large part in NMN manufacture, but there is no available NMN… read more here.
Keywords: nicotinamide mononucleotide; quality; novel hplc; hplc method ... See more keywords
Determination of Zoledronic Acid and Its Related Substances by High Performance Liquid Chromatography with Evaporative Light Scattering Detection.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of chromatographic science"
DOI: 10.1093/chromsci/bmy078
Abstract: A method has been developed and validated for analysis of zoledronic acid (ZOL) and its related substances by ion-pair reversed-phase high performance liquid chromatography with evaporative light scattering detection (ELSD). Chromatographic separation was achieved with… read more here.
Keywords: acid; related substances; high performance; performance liquid ... See more keywords
Simultaneous Quantitation of Paracetamol and Lornoxicam in Presence of Five Related Substances and Toxic Impurities by a Selective HPLC-DAD Method.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of AOAC International"
DOI: 10.1093/jaoacint/qsac032
Abstract: OBJECTIVE This research describes the simultaneous quantitation of Paracetamol (PRM) and Lornoxicam (LRX) with five of their related substances and toxic impurities, including, 4-nitrophenol (NTP), 4-aminophenol (AMP), 4-chloroacetanilide (CAC), N-phenylacetamide (NPA), and 2-aminopyridine (APD) using… read more here.
Keywords: toxic impurities; method; related substances; prm lrx ... See more keywords
Caste-specific storage of dopamine-related substances in the brains of four Polistes paper wasp species
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0280881
Abstract: How the role of dopamine differs according to the evolution of eusociality and how it is required in the flexible society of Polistes paper wasps need further clarification. In the present study, we compared the… read more here.
Keywords: related substances; dopamine related; levels dopamine; polistes paper ... See more keywords
Stability-Indicating Method of Entacapone-Related Substances Using UPLC in Finished Dosage Form
Sign Up to like & getrecommendations! Published in 2018 at "Current Science"
DOI: 10.18520/cs/v114/i03/644-649
Abstract: A rapid, specific, sensitive and robust method for entacapone-related substances in carbidopa, entacapone and levodopa film-coated tablet was developed using ACQUITY UPLC with BEH C18 column. Mobile phase (A), i.e. 0.1% orthophosphoric acid and mobile… read more here.
Keywords: method entacapone; stability indicating; method; entacapone ... See more keywords
Simultaneous Determination of Esafoxolaner, Eprinomectin, Praziquantel, BHT and Their Related Substances in a Topical Finished Product by a Single Reversed-Phase High-Performance Liquid Chromatography Method.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chromatographic science"
DOI: 10.2139/ssrn.3977498
Abstract: The topical product with three active pharmaceutical ingredients (APIs), namely, esafoxolaner, eprinomectin and praziquantel has demonstrated its efficacy in the treatment of cats with mixed infections with ectoparasites and nematodes and cestodes. A reversed-phase high-performance… read more here.
Keywords: esafoxolaner eprinomectin; bht; product; method ... See more keywords
Determination of related substances in egg yolk lecithin by HPLC-CAD and characterization of its profiling by HPLC-Q-TOF-MS.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.2139/ssrn.4176903
Abstract: A high-performance liquid chromatography (HPLC) method has been developed for the determination of related substances in egg yolk lecithin. Chromatographic separation was achieved using a gradient elution on a Waters Xbridge HILIC column maintained at… read more here.
Keywords: yolk lecithin; substances egg; hplc; egg yolk ... See more keywords