Influence of genetic variants in asparaginase pathway on the susceptibility to asparaginase-related toxicity and patients' outcome in childhood acute lymphoblastic leukemia
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-021-04290-6
Abstract: Asparaginase (ASNase) is a key component in the treatment protocols of childhood acute lymphoblastic leukemia (ALL). Asparagine synthetase (ASNS) and the basic region leucine zipper activating transcription factor 5 (ATF5) mediate the anti-leukemic effect of… read more here.
Keywords: childhood acute; related toxicity; lymphoblastic leukemia; toxicity ... See more keywords
Role of endocytotic uptake routes in impacting the ROS-related toxicity of silver nanoparticles to Mytilus galloprovincialis: A redox proteomic investigation.
Sign Up to like & getrecommendations! Published in 2018 at "Aquatic toxicology"
DOI: 10.1016/j.aquatox.2018.04.013
Abstract: Oxidative stress is often implicated in nanoparticle toxicity. Several studies have highlighted the role of internalization routes in determining nanotoxicity. Here, we investigate how two endocytotic mechanisms (clathrin- and caveolae-mediated) impact on redox balance in… read more here.
Keywords: ros related; silver nanoparticles; mytilus galloprovincialis; related toxicity ... See more keywords
Safety and tolerability of isoniazid preventive therapy for tuberculosis for persons with HIV with and without alcohol use: a single arm trial.
Sign Up to like & getrecommendations! Published in 2023 at "AIDS"
DOI: 10.1097/qad.0000000000003613
Abstract: OBJECTIVE Isoniazid (INH) preventive therapy is recommended to prevent tuberculosis (TB) disease for persons with HIV (PWH), except for those with regular and heavy alcohol consumption, due to hepatotoxicity concerns. We aimed to quantify the… read more here.
Keywords: alcohol; inh related; related toxicity; alcohol use ... See more keywords
Characteristics of fatal tapentadol-related toxicity in Australia.
Sign Up to like & getrecommendations! Published in 2022 at "Drug and alcohol review"
DOI: 10.1111/dar.13462
Abstract: INTRODUCTION Tapentadol is a centrally acting opioid analgesic prescribed for the treatment of moderate to severe pain. The study aimed to determine the characteristics of Australian toxicity deaths related to tapentadol. METHODS All cases in… read more here.
Keywords: tapentadol related; toxicity; characteristics fatal; related toxicity ... See more keywords
Risk Factors for Chemotherapy-Related Toxicity and Adverse Events in Elderly Thai Cancer Patients: A Prospective Study
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DOI: 10.1159/000485078
Abstract: Objectives: To assess factors predisposing to severe chemotherapy-related toxicity and adverse events (AEs) and dose modification in aging cancer patients. Methods: Cancer patients aged ≥70 years scheduled to receive the first cycle of a new… read more here.
Keywords: chemotherapy; related toxicity; toxicity; chemotherapy related ... See more keywords
Role of microRNAs in fluoropyrimidine-related toxicity: what we know.
Sign Up to like & getrecommendations! Published in 2021 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202104_25742
Abstract: Although more than half a century has passed since the discovery of fluoropyrimidines, they are still used in the treatment of many types of cancer, and it is estimated that annually two million patients undergo… read more here.
Keywords: fluoropyrimidine related; micrornas fluoropyrimidine; fluoropyrimidine toxicity; related toxicity ... See more keywords
Management and Prevention of Cellular-Therapy-Related Toxicity: Early and Late Complications
Sign Up to like & getrecommendations! Published in 2023 at "Current Oncology"
DOI: 10.3390/curroncol30050378
Abstract: Chimeric Antigen Receptor T (CAR-T) cell therapy has dramatically changed prognosis and treatment of relapsed and refractory hematologic malignancies. Currently the 6 FDA approved products target various surface antigens. While CAR-T therapy achieves good response,… read more here.
Keywords: cell; early late; therapy; car ... See more keywords