Structure-activity relationship study of tetrapeptide inhibitors of the Vascular Endothelial Growth Factor A binding to Neuropilin-1
Sign Up to like & getrecommendations! Published in 2017 at "Peptides"
DOI: 10.1016/j.peptides.2017.06.003
Abstract: HIGHLIGHTS13 tetrapeptides were synthesized, tested for inhibitory activity on VEGF165/NRP‐1 binding and modeled by molecular dynamics.Arg or Har in 1st position allow optimal interactions with NRP‐1 (length and delocalized charge of guanidinium group).Rigidity of central… read more here.
Keywords: relationship study; position; activity relationship; structure activity ... See more keywords
Structure-Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) Inhibitors.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c02156
Abstract: LSD1 is identified as an essential drug target, which is closely correlated to the development of several tumor types. In this work, on the basis of comprehensive analysis of the binding site of LSD1 and… read more here.
Keywords: structure activity; study indolin; relationship study; lsd1 inhibitors ... See more keywords
A focused structure-activity relationship study of psoralen-based immunoproteasome inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "MedChemComm"
DOI: 10.1039/c9md00365g
Abstract: The immunoproteasome is a multicatalytic protease that is predominantly expressed in cells of hematopoietic origin. Its elevated expression has been associated with autoimmune diseases, various types of cancer, and inflammatory diseases. The development of immunoproteasome-selective… read more here.
Keywords: study psoralen; relationship study; focused structure; activity relationship ... See more keywords