Structure‐Activity Relationships for 5′′ Modifications of 4,5‐Aminoglycoside Antibiotics
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DOI: 10.1002/cmdc.202200120
Abstract: Modification at the 5’’‐position of 4,5‐disubstituted aminoglycoside antibiotics (AGAs) to circumvent inactivation by aminoglycoside modifying enzymes (AMEs) is well known. Such modifications, however, unpredictably impact activity and affect target selectivity thereby hindering drug development. A… read more here.
Keywords: structure activity; activity; activity relationships; aminoglycoside antibiotics ... See more keywords