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   Articles with "relative bioavailability" as a keyword



Phase 1 Studies to Evaluate the Food Effect and Relative Bioavailability of Tablet and Capsule Formulations of Belumosudil in Healthy Adult Subjects.

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recommendations! Published in 2022 at "Clinical pharmacology in drug development"

DOI: 10.1002/cpdd.1083

Abstract: Belumosudil is a selective Rho-associated coiled-coil containing protein kinase 2 inhibitor. A capsule formulation was used during early clinical development of belumosudil; it was later replaced by a tablet formulation, which mimicked the capsule's release… read more here.

Keywords: phase studies; food; relative bioavailability; belumosudil ... See more keywords

Relative Bioavailability Studies With Mitapivat: Formulation and Food Effect Assessments in Healthy Subjects

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recommendations! Published in 2024 at "Clinical Pharmacology in Drug Development"

DOI: 10.1002/cpdd.1481

Abstract: Pyruvate kinase (PK) deficiency is a rare, hereditary, hemolytic anemia caused by mutations in the PKLR gene encoding the PK enzyme. Mitapivat (previously designated AG‐348) is a first‐in‐class, oral, allosteric activator of PK. We report… read more here.

Keywords: relative bioavailability; food; mitapivat; bioavailability studies ... See more keywords

Taste Profile and Relative Bioavailability of Tovorafenib Powder for Oral Suspension and Food Effect of the Tovorafenib Tablet in Healthy Participants

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recommendations! Published in 2025 at "Clinical Pharmacology in Drug Development"

DOI: 10.1002/cpdd.1558

Abstract: A pediatric‐friendly powder for oral suspension (PfOS) of tovorafenib, a type II RAF inhibitor, was developed for patients with difficulty swallowing tablets. This open‐label, randomized, phase 1 study (QSC205140) evaluated the taste/palatability of PfOS formulations… read more here.

Keywords: relative bioavailability; food; powder oral; tablet ... See more keywords

Relative Bioavailability, Food Effect, and Bioequivalence Studies to Assess a New Zanubrutinib 160-mg Tablet: Results From 2 Phase 1 Studies in Healthy Volunteers.

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recommendations! Published in 2025 at "Clinical pharmacology in drug development"

DOI: 10.1002/cpdd.1584

Abstract: Zanubrutinib is a next-generation Bruton tyrosine kinase inhibitor approved for treating B-cell malignancies. Two phase 1 studies evaluated a new 160-mg zanubrutinib tablet versus 80-mg capsules. In study BGB-3111-115 (n = 43), a randomized 3-period crossover trial,… read more here.

Keywords: relative bioavailability; food; bioavailability food; phase studies ... See more keywords

Comparison of mouse and swine bioassays for determination of soil arsenic relative bioavailability.

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recommendations! Published in 2017 at "Applied Geochemistry"

DOI: 10.1016/j.apgeochem.2017.05.016

Abstract: Abstract Evaluation of soil arsenic (As) relative bioavailability (RBA) is essential to accurately assess human exposure to As contaminated soils via the incidental ingestion pathway. A variety of animal bioassays have been developed to estimate… read more here.

Keywords: rba; relative bioavailability; soil arsenic; swine ... See more keywords

Can in vitro assays account for interactions between inorganic co-contaminants observed during in vivo relative bioavailability assessment?

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recommendations! Published in 2018 at "Environmental pollution"

DOI: 10.1016/j.envpol.2017.10.089

Abstract: In vitro assays act as surrogate measurements of relative bioavailability (RBA) for inorganic contaminants. The values derived from these assays are routinely used to refine human health risk assessments (HHRA). Extensive in vitro research has been performed… read more here.

Keywords: relative bioavailability; inorganic contaminants; vitro assays; bioavailability ... See more keywords

Comparative evaluation of in vivo relative bioavailability and in vitro bioaccessibility of arsenic in leafy vegetables and its implication in human exposure assessment.

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recommendations! Published in 2021 at "Journal of hazardous materials"

DOI: 10.1016/j.jhazmat.2021.126909

Abstract: Arsenic (As) contamination in vegetables is a severe threat to human health. However, the evaluation of As relative bioavailability (As-RBA) or bioaccessibility in vegetables is still unexplored. The study sought to evaluate the As-RBA in… read more here.

Keywords: relative bioavailability; vivo; bioavailability; exposure ... See more keywords
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Intra- and inter-laboratory evaluation of an assay of soil arsenic relative bioavailability in mice.

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recommendations! Published in 2020 at "Journal of agricultural and food chemistry"

DOI: 10.1021/acs.jafc.9b06537

Abstract: Hand-to-mouth activity in children can be an important route for ingestion of soil and dust contaminated with inorganic arsenic. Estimating the relative bioavailability of arsenic present in these media is a critical element in assessing… read more here.

Keywords: relative bioavailability; bioavailability; inter laboratory; laboratory ... See more keywords
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Relative bioavailability of guanidinoacetic acid delivered ruminally or abomasally to cattle.

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recommendations! Published in 2020 at "Journal of animal science"

DOI: 10.1093/jas/skaa282

Abstract: This study assessed relative bioavailability of guanidinoacetic acid (GAA) in cattle. Seven ruminally cannulated Holstein steers (initial body weight of 280 kg) were used in an experiment with a 5 × 5 Latin square design; the… read more here.

Keywords: relative bioavailability; guanidinoacetic acid; infusion; bioavailability guanidinoacetic ... See more keywords

Relative bioavailability of 25-hydroxycholecalciferol versus cholecalciferol and vitamin D3 requirements in White Pekin ducks from 15 to 42 days of age.

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recommendations! Published in 2025 at "Journal of animal science"

DOI: 10.1093/jas/skaf184

Abstract: This study was designed to assess the effects of varying levels of vitamin D3 (VD3) or 25-hydroxycholecalciferol (25-OH-D3) supplementary in the diet on growth performance, VD3 status, plasma calcium (Ca) levels, and tibial mineralization in… read more here.

Keywords: relative bioavailability; pekin ducks; vitamin; hydroxycholecalciferol ... See more keywords

359 Determination of relative bioavailability of copper from GemStone® copper in growing beef steers

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recommendations! Published in 2019 at "Journal of Animal Science"

DOI: 10.1093/jas/skz122.262

Abstract: To evaluate bioavailability of Cu from Cu glycinate (CuGly; GemStoneCu; Phibro Animal Health Corporation) vs. Cu sulfate (CuSO4) in diets supplemented with 0.3% S and 2 mg Mo/kg DM 60 Angus-cross steers (288 ±26 kg… read more here.

Keywords: bioavailability; copper; liver concentrations; relative bioavailability ... See more keywords