Phase 1 Studies to Evaluate the Food Effect and Relative Bioavailability of Tablet and Capsule Formulations of Belumosudil in Healthy Adult Subjects.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical pharmacology in drug development"
DOI: 10.1002/cpdd.1083
Abstract: Belumosudil is a selective Rho-associated coiled-coil containing protein kinase 2 inhibitor. A capsule formulation was used during early clinical development of belumosudil; it was later replaced by a tablet formulation, which mimicked the capsule's release… read more here.
Keywords: phase studies; food; relative bioavailability; belumosudil ... See more keywords
Comparison of mouse and swine bioassays for determination of soil arsenic relative bioavailability.
Sign Up to like & getrecommendations! Published in 2017 at "Applied Geochemistry"
DOI: 10.1016/j.apgeochem.2017.05.016
Abstract: Abstract Evaluation of soil arsenic (As) relative bioavailability (RBA) is essential to accurately assess human exposure to As contaminated soils via the incidental ingestion pathway. A variety of animal bioassays have been developed to estimate… read more here.
Keywords: rba; relative bioavailability; soil arsenic; swine ... See more keywords
Can in vitro assays account for interactions between inorganic co-contaminants observed during in vivo relative bioavailability assessment?
Sign Up to like & getrecommendations! Published in 2018 at "Environmental pollution"
DOI: 10.1016/j.envpol.2017.10.089
Abstract: In vitro assays act as surrogate measurements of relative bioavailability (RBA) for inorganic contaminants. The values derived from these assays are routinely used to refine human health risk assessments (HHRA). Extensive in vitro research has been performed… read more here.
Keywords: relative bioavailability; inorganic contaminants; vitro assays; bioavailability ... See more keywords
Comparative evaluation of in vivo relative bioavailability and in vitro bioaccessibility of arsenic in leafy vegetables and its implication in human exposure assessment.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of hazardous materials"
DOI: 10.1016/j.jhazmat.2021.126909
Abstract: Arsenic (As) contamination in vegetables is a severe threat to human health. However, the evaluation of As relative bioavailability (As-RBA) or bioaccessibility in vegetables is still unexplored. The study sought to evaluate the As-RBA in… read more here.
Keywords: relative bioavailability; vivo; bioavailability; exposure ... See more keywords
Intra- and inter-laboratory evaluation of an assay of soil arsenic relative bioavailability in mice.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.9b06537
Abstract: Hand-to-mouth activity in children can be an important route for ingestion of soil and dust contaminated with inorganic arsenic. Estimating the relative bioavailability of arsenic present in these media is a critical element in assessing… read more here.
Keywords: relative bioavailability; bioavailability; inter laboratory; laboratory ... See more keywords
Relative bioavailability of guanidinoacetic acid delivered ruminally or abomasally to cattle.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of animal science"
DOI: 10.1093/jas/skaa282
Abstract: This study assessed relative bioavailability of guanidinoacetic acid (GAA) in cattle. Seven ruminally cannulated Holstein steers (initial body weight of 280 kg) were used in an experiment with a 5 × 5 Latin square design; the… read more here.
Keywords: relative bioavailability; guanidinoacetic acid; infusion; bioavailability guanidinoacetic ... See more keywords
359 Determination of relative bioavailability of copper from GemStone® copper in growing beef steers
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Animal Science"
DOI: 10.1093/jas/skz122.262
Abstract: To evaluate bioavailability of Cu from Cu glycinate (CuGly; GemStoneCu; Phibro Animal Health Corporation) vs. Cu sulfate (CuSO4) in diets supplemented with 0.3% S and 2 mg Mo/kg DM 60 Angus-cross steers (288 ±26 kg… read more here.
Keywords: bioavailability; copper; liver concentrations; relative bioavailability ... See more keywords
Relative bioavailability of delamanid 50 mg tablets dispersed in water in healthy adult volunteers.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of clinical pharmacology"
DOI: 10.1111/bcp.15672
Abstract: AIM Delamanid is a novel drug to treat of drug-resistant tuberculosis, manufactured as 50 mg solid and 25 mg dispersible tablets. We evaluated the effects of dispersing the 50 mg tablet, focusing on the relative… read more here.
Keywords: relative bioavailability; healthy adult; delamanid tablets; bioavailability ... See more keywords
Relative Bioavailability and Food Effect Study of an Oral Suspension of Alectinib in Healthy Volunteers Using Venipuncture and Capillary Microsampling.
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DOI: 10.1111/cts.13515
Abstract: Alectinib, approved as 150 mg capsules for the treatment of adults with advanced ALK-positive non-small-cell lung cancer, is being assessed in children with ALK-positive solid and central nervous system tumors. An ad hoc pediatric-friendly suspension… read more here.
Keywords: relative bioavailability; suspension alectinib; capsule; suspension ... See more keywords
An open‐label, phase 1, randomized, three treatments, three‐period, crossover, relative bioavailability study of CC‐292, a potent and orally available inhibitor of bruton tyrosine kinase
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Pharmacy and Therapeutics"
DOI: 10.1111/jcpt.13653
Abstract: CC‐292 is a potent, selective, orally administered small molecule inhibitor of bruton tyrosine kinase (BTK). The aim of this study was to evaluate the relative bioavailability of newly developed CC‐292 tablet formulation (P22 tablet (P22‐TAB)… read more here.
Keywords: 292 potent; bruton tyrosine; relative bioavailability; inhibitor bruton ... See more keywords
A phase 1, randomized, open-label, single-dose study to assess the relative bioavailability of a subcutaneous dose of FKB327 when administered using a prefilled syringe, a prefilled auto-injector, or a vial with disposable syringe in healthy subjects
Sign Up to like & getrecommendations! Published in 2019 at "BMC Pharmacology & Toxicology"
DOI: 10.1186/s40360-019-0376-9
Abstract: Background/objectiveFKB327 is a biosimilar of the adalimumab reference product (RP). The primary objective was to assess the relative bioavailability of FKB327 after a single subcutaneous (SC) dose via prefilled syringe (PFS), auto-injector (AI), or vial… read more here.
Keywords: assess relative; relative bioavailability; fkb327; syringe ... See more keywords