Relative configuration of Cys‐Pro ester peptides in thioester formation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Peptide Science"
DOI: 10.1002/psc.3406
Abstract: A peptide containing a cysteinyl prolyl ester (CPE) moiety at the C‐terminus (CPE peptide) was transformed into a diketopiperazine (DKP) thioester via an intramolecular N–S acyl shift reaction and was then used for peptide ligation.… read more here.
Keywords: cys pro; ester; pro ester; ester peptides ... See more keywords
The relevance of the relative configuration in the folding of hybrid peptides containing β-cyclobutane amino acids and γ-amino-l-proline residues
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron"
DOI: 10.1016/j.tet.2017.09.011
Abstract: Abstract Four new series of diastereomeric β,γ-di- and β,γ-tetrapeptides derived from conveniently protected (1 R ,2 S )- and (1 S ,2S)-2-aminocyclobutane-1-carboxylic acid and cis - and trans -γ-amino- l -proline joined in alternation have… read more here.
Keywords: relative configuration; amino proline; cyclobutane amino; peptides containing ... See more keywords
Synthesis of 7,6-Spirocyclic Imine with Butenolide Ring Provides Evidence for the Relative Configuration of Marine Toxin 13-desMe Spirolide C.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b03373
Abstract: Efficient synthesis of the partial structure of marine toxin 13-desMe spirolide C was achieved via the selective Diels-Alder reaction and C-C bond formation with the use of a silatrane substituent and the subsequent facile formation… read more here.
Keywords: desme spirolide; configuration; relative configuration; marine toxin ... See more keywords
Progressive Stereo Locking (PSL): A Residual Dipolar Coupling Based Force Field Method for Determining the Relative Configuration of Natural Products and Other Small Molecules.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.7b00281
Abstract: Establishing the relative configuration of a bioactive natural product represents the most challenging part in determining its structure. Residual dipolar couplings (RDCs) are sensitive probes of the relative spatial orientation of internuclear vectors. We adapted… read more here.
Keywords: force field; residual dipolar; configuration; relative configuration ... See more keywords
Relative configuration of micrograms of natural compounds using proton residual chemical shift anisotropy
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-18093-5
Abstract: 3D molecular structure determination is a challenge for organic compounds or natural products available in minute amounts. Proton/proton and proton/carbon correlations yield the constitution. J couplings and NOEs oftentimes supported by one-bond 1H,13C residual dipolar… read more here.
Keywords: configuration; relative configuration; residual chemical; chemical shift ... See more keywords
Determining the Relative Configuration of Propargyl Cyclopropanes by Co-Crystallization
Sign Up to like & getrecommendations! Published in 2020 at "Synlett"
DOI: 10.1055/a-1293-9867
Abstract: Determining the diastereoselectivity of new synthetic molecules can be a challenge when NMR methods fail and the compounds are difficult to crystallize. Encapsulating organic crystals can be used to overcome this challenge. Here we show… read more here.
Keywords: relative configuration; determining relative; propargyl cyclopropanes; crystallization ... See more keywords