Relative Nuclease Resistance of a DNA Aptamer Covalently Conjugated to a Target Protein
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DOI: 10.3390/ijms23147778
Abstract: A major obstacle to the therapeutic application of an aptamer is its susceptibility to nuclease digestion. Here, we confirmed the acquisition of relative nuclease resistance of a DNA-type thrombin binding aptamer with a warhead (TBA3)… read more here.
Keywords: nuclease resistance; resistance; target protein; relative nuclease ... See more keywords