The contribution of beta-2 adrenergic, muscarinic and histamine (H1) receptors, calcium and potassium channels and cyclooxygenase pathway in the relaxant effect of Allium cepa L. on the tracheal smooth muscle.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2019.112012
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE There are report regarding therapeutic effects for Allium cepa L. (A. cepa) in Iranian traditional medicine and the plant has showed anti-inflammatory, anti-allergic, anti-hyperglycemic, antioxidant, anti-cancer, anti-hypertension, anti-hypercholesterolemia and anti-asthmatic activities in previous… read more here.
Keywords: cepa extract; cepa; effect; relaxant effects ... See more keywords
Mechanism of action of relaxant effect of Agastache mexicana ssp.mexicana essential oil in guinea-pig trachea smooth muscle
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DOI: 10.1080/13880209.2016.1230140
Abstract: Abstract Context: Agastache mexicana ssp. mexicana (Kunth) Lint & Epling (Lamiaceae), popularly known as ‘toronjil morado’, is used in Mexican traditional medicine for the treatment of several diseases such as hypertension, anxiety and respiratory disorders.… read more here.
Keywords: effect; guinea pig; relaxant effect; effect ameo ... See more keywords
Calcium and potassium channels are involved in curcumin relaxant effect on tracheal smooth muscles
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DOI: 10.1080/13880209.2020.1723647
Abstract: Abstract Context Curcumin, the active component of Curcuma longa L. (Zingiberaceae), exhibits a wide variety of biological activities including vasodilation and anti-inflammation. Objective The relaxant effect of curcumin in tracheal smooth muscle (TSM) was not… read more here.
Keywords: effect curcumin; tracheal smooth; effect; non incubated ... See more keywords
Assessment of the Airway Smooth Muscle Relaxant Effect of Drotaverine
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DOI: 10.1159/000485921
Abstract: Background: Drotaverine, a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor, blocks the degradation of 3’,5’-cyclic adenosine monophosphate. However, published receptor binding data showed that drotaverin also binds to the L-type voltage-operated calcium channel (L-VOCC). Based… read more here.
Keywords: muscle relaxant; drotaverine; smooth muscle; relaxant effect ... See more keywords
Quinazoline-based human phosphodiesterase 5 inhibitors exhibited a selective vasorelaxant effect on rat isolated pulmonary arteries involving NO-sGC-cGMP pathway and calcium inhibitory effects.
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DOI: 10.2139/ssrn.4197599
Abstract: Phosphodiesterase 5 (PDE5) inhibitors are an attractive option among the currently available therapies in the management of pulmonary arterial hypertension (PAH). Good selectivity for PDE5 is associated with reduced side effects and greater vasorelaxant effect… read more here.
Keywords: vasorelaxant effect; rat isolated; effect; quinazoline based ... See more keywords
Contribution of potassium channels, beta2-adrenergic and histamine H1 receptors in the relaxant effect of baicalein on rat tracheal smooth muscle
Sign Up to like & getrecommendations! Published in 2019 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2019.36377.8666
Abstract: Objective(s): Baicalein, a compound extracted from a variety of herbs, showed various pharmacological effects. This study evaluated the relaxant effects of baicalein and its underlying molecular mechanisms of action on rat’s isolated tracheal smooth muscle.… read more here.
Keywords: baicalein; tracheal smooth; effect; smooth muscle ... See more keywords
β3 Relaxant Effect in Human Bladder Involves Cystathionine γ-Lyase-Derived Urothelial Hydrogen Sulfide
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DOI: 10.3390/antiox11081480
Abstract: It is now well established that the urothelium does not act as a passive barrier but contributes to bladder homeostasis by releasing several signaling molecules in response to physiological and chemical stimuli. Here, we investigated… read more here.
Keywords: bladder; effect; relaxant effect; human bladder ... See more keywords
Relaxant Effect of Monoterpene (−)-Carveol on Isolated Human Umbilical Cord Arteries and the Involvement of Ion Channels
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DOI: 10.3390/molecules25112681
Abstract: Carveol is a monoterpene present in the structure of many plant products. It has a variety of biological activities: antioxidant, anticancer and vasorelaxation. However, studies investigating the effect of monoterpenoids on human vessels have not… read more here.
Keywords: carveol; effect monoterpene; effect; human umbilical ... See more keywords