Substitutions in Spodoptera exigua topoisomerase I modulate its relaxation activity and camptothecin sensitivity.
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DOI: 10.1002/ps.4440
Abstract: BACKGROUND Topoisomerase I (Top I) is referred as the cellular target of the camptothecins (CPTs) which are now being explored as potential pesticides for insect control. Three amino acid substitutions, including L530P, A653T and S729T,… read more here.
Keywords: relaxation; sensitivity; topoisomerase; spodoptera exigua ... See more keywords