Administration study of recombinant human relaxin-2 in horse for doping control purpose.
Sign Up to like & getrecommendations! Published in 2019 at "Drug testing and analysis"
DOI: 10.1002/dta.2732
Abstract: The insulin-like peptide relaxin (RLX), an endogenous peptide hormone produced in human for pregnancy and reproduction, is also known to exert a range of physiological and pathological effects. Its use is banned in human sports,… read more here.
Keywords: administration; doping control; administration study; control purpose ... See more keywords
The relationship of circulating relaxin‐2 concentrations with short‐term prognosis in patients with acute heart failure: the RELAHF study
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.875
Abstract: Aims This study aimed to determine the frequency of detectable relaxin-2 concentrations and associated factors in patients with acute heart failure (AHF) and to establish relationships with short-term outcome and clinical and analytical parameters. Methods… read more here.
Keywords: study; relaxin concentrations; heart failure; relaxin ... See more keywords
The relaxin family peptide receptor 1 (RXFP1): An emerging player in human health and disease
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.1194
Abstract: Relaxin/relaxin family peptide receptor 1 (RXFP1) signaling is important for both normal physiology and disease. Strong preclinical evidence supports relaxin as a potent antifibrotic molecule. However, relaxin‐based therapy failed in clinical trial in patients with… read more here.
Keywords: rxfp1; relaxin family; family peptide; peptide receptor ... See more keywords
Relaxin-3/RXFP3 signalling in mouse hypothalamus: no effect of RXFP3 activation on corticosterone, despite reduced presynaptic excitatory input onto paraventricular CRH neurons in vitro
Sign Up to like & getrecommendations! Published in 2017 at "Psychopharmacology"
DOI: 10.1007/s00213-017-4575-z
Abstract: Relaxin-3/RXFP3 signalling is proposed to be involved in the neuromodulatory control of arousal- and stress-related neural circuits. Furthermore, previous studies in rats have led to the proposal that relaxin-3/RXFP3 signalling is associated with activation of… read more here.
Keywords: corticosterone; rxfp3; crh neurons; relaxin rxfp3 ... See more keywords
A validated UPLC-MS/MS method coupled with protein precipitation and ion exchange solid phase extraction for the quantitation of porcine relaxin B29 in dog plasma and its application to a pharmacokinetic study
Sign Up to like & getrecommendations! Published in 2017 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-017-0604-3
Abstract: AbstractPorcine relaxin is a 6 kDa peptide hormone of pregnancy with important physiological and pharmacological effects. It contains a number of analogs of which porcine relaxin B29 is one of the most important. To support… read more here.
Keywords: porcine relaxin; relaxin b29; method; ion ... See more keywords
Serum relaxin level predicts recurrence of atrial fibrillation after radiofrequency catheter ablation
Sign Up to like & getrecommendations! Published in 2019 at "Heart and Vessels"
DOI: 10.1007/s00380-019-01386-1
Abstract: Relaxin, an emerging biomarker in heart failure, is involved in fibrosis and inflammation. The value of relaxin in predicting recurrence of atrial fibrillation (AF) after radiofrequency catheter ablation (RFCA) is unknown and the subject of… read more here.
Keywords: pre rfca; relaxin level; recurrence; relaxin ... See more keywords
Relaxin activates AMPK-AKT signaling and increases glucose uptake by cultured cardiomyocytes
Sign Up to like & getrecommendations! Published in 2018 at "Endocrine"
DOI: 10.1007/s12020-018-1534-3
Abstract: PurposeMany evidences show that the hormone relaxin plays a pivotal role in the physiology and pathology of the cardiovascular system. This pleiotropic hormone exerts regulatory functions through specific receptors in cardiovascular tissues: in experimental animal… read more here.
Keywords: cardiomyocytes relaxin; glucose uptake; activates ampk; relaxin ... See more keywords
Endurance exercise improves avoidance learning and spatial memory, through changes in genes of GABA and relaxin-3, in rats.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.05.080
Abstract: Different exercise patterns, neurotransmitters, and some genes have numerous effects on learning and memory. This research aims to investigate the long-term effects of submaximal aerobic exercise on spatial memory (SM), passive avoidance learning (PAL), levels… read more here.
Keywords: gad65; avoidance learning; spatial memory; exercise ... See more keywords
Relaxin 2 carried by magnetically directed liposomes accelerates rat midpalatal suture expansion and subsequent new bone formation
Sign Up to like & getrecommendations! Published in 2019 at "Bone Reports"
DOI: 10.1016/j.bonr.2019.100202
Abstract: Relaxin (RLN) is an insulin-like peptide hormone that enables softening and lengthening of the pubic symphysis and uterine cervix. Here, we analyzed the effects of RLN2 on the expansion of rat midpalatal suture (MPS) using… read more here.
Keywords: expansion; bone formation; bone; rln lipo ... See more keywords
Targeted viral vector transduction of relaxin-3 neurons in the rat nucleus incertus using a novel cell-type specific promoter
Sign Up to like & getrecommendations! Published in 2020 at "IBRO Reports"
DOI: 10.1016/j.ibror.2019.11.006
Abstract: Highlights • Extensive, ascending relaxin-3-containing neural networks are present throughout the rat forebrain.• Relaxin-3 signalling modulates complex behaviours and cognitive processes including feeding, anxiety and memory.• We tested a 1736 bp promoter sequence for specific… read more here.
Keywords: nucleus incertus; promoter; rat nucleus; neurons rat ... See more keywords
Multi-Component Mechanism of H2 Relaxin Binding to RXFP1 through NanoBRET Kinetic Analysis
Sign Up to like & getrecommendations! Published in 2019 at "iScience"
DOI: 10.1016/j.isci.2018.12.004
Abstract: Summary The peptide hormone H2 relaxin has demonstrated promise as a therapeutic, but mimetic development has been hindered by the poorly understood relaxin receptor RXFP1 activation mechanism. H2 relaxin is hypothesized to bind to two… read more here.
Keywords: rxfp1; relaxin binding; multi component; mechanism relaxin ... See more keywords