The relaxin family peptide receptor 1 (RXFP1): An emerging player in human health and disease
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.1194
Abstract: Relaxin/relaxin family peptide receptor 1 (RXFP1) signaling is important for both normal physiology and disease. Strong preclinical evidence supports relaxin as a potent antifibrotic molecule. However, relaxin‐based therapy failed in clinical trial in patients with… read more here.
Keywords: rxfp1; relaxin family; family peptide; peptide receptor ... See more keywords
Overexpression of relaxin family peptide receptor 3 in Escherichia coli and characterization of its ligand binding properties
Sign Up to like & getrecommendations! Published in 2018 at "Process Biochemistry"
DOI: 10.1016/j.procbio.2018.03.022
Abstract: Abstract Relaxin family peptide receptor 3 (RXFP3) is an A-class G protein-coupled receptor. It is implicated in the regulation of food intake and stress response upon activation by the neuropeptide relaxin-3. So far, preparation of… read more here.
Keywords: rxfp3; relaxin family; escherichia coli; family peptide ... See more keywords
Development of a selective agonist for relaxin family peptide receptor 3
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-03465-7
Abstract: Relaxin family peptides perform a variety of biological functions by activating four G protein-coupled receptors, namely RXFP1–4. Among these receptors, RXFP3 lacks a specific natural or synthetic agonist at present. A previously designed chimeric R3/I5… read more here.
Keywords: towards rxfp3; selective agonist; relaxin family; agonist ... See more keywords
Signal transduction pathways activated by insulin‐like peptide 5 at the relaxin family peptide RXFP4 receptor
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Pharmacology"
DOI: 10.1111/bph.13522
Abstract: Insulin‐like peptide 5 (INSL5) is a two‐chain, three‐disulfide‐bonded peptide of the insulin/relaxin superfamily, uniquely expressed in enteroendocrine L‐cells of the colon. It is the cognate ligand of relaxin family peptide RXFP4 receptor that is mainly… read more here.
Keywords: insulin; peptide; relaxin family; family peptide ... See more keywords
Relaxin family peptides: structure–activity relationship studies
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Pharmacology"
DOI: 10.1111/bph.13684
Abstract: The human relaxin peptide family consists of seven cystine‐rich peptides, four of which are known to signal through relaxin family peptide receptors, RXFP1–4. As these peptides play a vital role physiologically and in various diseases,… read more here.
Keywords: relaxin family; family; activity relationship; structure activity ... See more keywords
Comparative Genomic Characterization of Relaxin Peptide Family in Cattle and Buffalo
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/1581714
Abstract: Relaxin family peptides significantly regulate reproduction, nutrient metabolism, and immune response in mammals. The present study aimed to identify and characterize the relaxin family peptides in cattle and buffalo at the genome level. The genomic… read more here.
Keywords: family peptides; relaxin family; cattle buffalo; relaxin ... See more keywords
Expression and Characterization of Relaxin Family Peptide Receptor 1 Variants
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.826112
Abstract: G-protein coupled receptors (GPCR) transduce extracellular stimuli into the cell interior and are thus centrally involved in almost all physiological-neuronal processes. This essential function and association with many diseases or pathological conditions explain why GPCRs… read more here.
Keywords: relaxin family; peptide receptor; expression; family peptide ... See more keywords