Stereoselective Alkyne-Alkene [2 + 2] Cycloaddition Enabled by Anion Relay Chemistry for Fully C-Substituted Cyclobutene Synthesis.
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DOI: 10.1021/acs.orglett.4c04255
Abstract: Cyclobutenes serve as valuable scaffolds in pharmaceutical development, but synthesizing structurally diverse fully C-substituted cyclobutenes remains challenging. Here we report a stereoselective [2 + 2] cycloaddition between alkynyl 1,3-dithianes and cinnamate esters using a catalytic… read more here.
Keywords: chemistry; anion relay; relay chemistry; fully substituted ... See more keywords
α-Silyl Amides: Effective Bifunctional Lynchpins for Type I Anion Relay Chemistry.
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DOI: 10.1021/acs.orglett.7b03142
Abstract: Lynchpins comprising α-silyl amides have been validated for type I anion relay chemistry (ARC) to permit ready access to γ-ketoamides. Importantly, the ARC protocol can be run at ambient temperature without the need of additional… read more here.
Keywords: chemistry; relay chemistry; type anion; anion relay ... See more keywords