RelB intrinsically regulates the development and function of medullary thymic epithelial cells
Sign Up to like & getrecommendations! Published in 2017 at "Science China Life Sciences"
DOI: 10.1007/s11427-017-9298-3
Abstract: Medullary thymic epithelial cells (mTECs) act as one of the major stromal components in the thymus for selection and maturation of both conventional T cells and non-conventional T cells. Extensive efforts have been spent to… read more here.
Keywords: epithelial cells; relb; thymic epithelial; development function ... See more keywords
A T cell-intrinsic function for NF-κB RelB in experimental autoimmune encephalomyelitis
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DOI: 10.1038/s41598-021-99134-x
Abstract: NF-kappaB (NF-κB) is a family of transcription factors with pleiotropic functions in immune responses. The alternative NF-κB pathway that leads to the activation of RelB and NF-κB2, was previously associated with the activation and function… read more here.
Keywords: relb; autoimmune encephalomyelitis; function; cell ... See more keywords
Nuclear Translocation of RELB Is Increased in Diseased Human Liver and Promotes Ductular Reaction and Biliary Fibrosis in Mice.
Sign Up to like & getrecommendations! Published in 2019 at "Gastroenterology"
DOI: 10.1053/j.gastro.2018.11.018
Abstract: BACKGROUND & AIMS Cholangiocyte proliferation and ductular reaction contribute to the onset and progression of liver diseases. Little is known about the role of the transcription factor nuclear factor-κB (NF-κB) in this process. We investigated… read more here.
Keywords: cyld; liver; relb; lpc mice ... See more keywords
RelB promotes liver fibrosis via inducing the release of injury‐associated inflammatory cytokines
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15108
Abstract: Liver fibrosis is a serious chronic disease that developed by a coordinated interplay of many cell types, but the underlying signal transduction in individual cell type remains to be characterized. Nuclear factor‐κB (NF‐κB) is a… read more here.
Keywords: liver fibrosis; relb; inflammatory cytokines; relb hep ... See more keywords
PO-513 The alternative NF-κB pathway in colorectal cancer. from genetic polymorphisms through mRNA to protein levels
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.1014
Abstract: Introduction In colorectal cancer (CRC), there is scarce information regarding the alternative NF-κB pathway which regulates different aspects of immune functions. Material and methods Formalin-fixed paraffin-embedded (FFPE) tissue samples from 116 patients with CRC were… read more here.
Keywords: protein; alternative pathway; relb; expression ... See more keywords
RelB‐Deficient Dendritic Cells Promote the Development of Spontaneous Allergic Airway Inflammation
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Respiratory Cell and Molecular Biology"
DOI: 10.1165/rcmb.2017-0242oc
Abstract: Abstract RelB is a member of the NF‐&kgr;B family, which is essential for dendritic cell (DC) function and maturation. However, the contribution of RelB to the development of allergic airway inflammation (AAI) is unknown. Here,… read more here.
Keywords: allergic airway; airway inflammation; relb; cell ... See more keywords
A detrimental role of RelB in mature oligodendrocytes during experimental acute encephalomyelitis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-019-1548-7
Abstract: BackgroundMultiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS). It is firmly established that overactivation of the p65 (RelA) nuclear factor kappa B (NF-κB) transcription factor upregulates expression of inflammatory… read more here.
Keywords: inflammation; cns; relb; role relb ... See more keywords
The relationship between the non-canonical NF-κB pathway, tumour microenvironment, systemic inflammation and survival in patients undergoing surgery for colorectal caner.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.4_suppl.631
Abstract: 631Background: In patients with colorectal cancer (CRC) the local and systemic inflammatory responses (LIR and SIR) are important determinants of disease progression. The present study examines the association of transcription factor RelB, a key member… read more here.
Keywords: canonical pathway; patients undergoing; relb; non canonical ... See more keywords
The Alternative RelB NF-kB Subunit Exerts a Critical Survival Function upon Metabolic Stress in Diffuse Large B-Cell Lymphoma-Derived Cells
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DOI: 10.3390/biomedicines10020348
Abstract: Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma in adults and reveals distinct genetic and metabolic signatures. NF-κB transcription factor family is involved in diverse biological processes enabling tumor development and resistance… read more here.
Keywords: relb; cell; lymphoma; dlbcl cell ... See more keywords