The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension
Sign Up to like & getrecommendations! Published in 2017 at "Cell"
DOI: 10.1016/j.cell.2017.04.013
Abstract: Summary The spatial organization of chromosomes influences many nuclear processes including gene expression. The cohesin complex shapes the 3D genome by looping together CTCF sites along chromosomes. We show here that chromatin loop size can… read more here.
Keywords: chromatin loop; cohesin; factor wapl; release factor ... See more keywords
Cultured bloodstream Trypanosoma brucei adapt to life without mitochondrial translation release factor 1
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-23472-6
Abstract: Trypanosoma brucei is an extracellular parasite that alternates between an insect vector (procyclic form) and the bloodstream of a mammalian host (bloodstream form). While it was previously reported that mitochondrial release factor 1 (TbMrf1) is… read more here.
Keywords: release factor; trypanosoma brucei; bloodstream; form ... See more keywords
The structural basis for release-factor activation during translation termination revealed by time-resolved cryogenic electron microscopy.
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.2210/pdb6osq/pdb
Abstract: When the ribosome encounters a stop codon, it recruits a release factor (RF) to hydrolyze the ester bond between the peptide chain and tRNA. RFs have structural motifs that recognize stop codons in the decoding… read more here.
Keywords: translation termination; time; release factor; microscopy ... See more keywords
A High-Throughput Assay for In Vitro Determination of Release Factor-Dependent Peptide Release from a Pretermination Complex by Fluorescence Anisotropy—Application to Nonsense Suppressor Screening and Mechanistic Studies
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13020242
Abstract: Premature termination codons (PTCs) account for ~12% of all human disease mutations. Translation readthrough-inducing drugs (TRIDs) are prominent among the several therapeutic approaches being used to overcome PTCs. Ataluren is the only TRID that has… read more here.
Keywords: dependent peptide; termination; release; peptide release ... See more keywords
High expression of density-regulated re-initiation and release factor drives tumourigenesis and affects clinical outcome
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DOI: 10.3892/ol.2018.9620
Abstract: Previously, certain experiments have suggested that density-regulated re-initiation and release factor (DENR) could serve important roles in cancer, however, to the best of our knowledge, a comprehensive analysis of DENR and its association with cancer… read more here.
Keywords: initiation release; denr; density regulated; expression ... See more keywords