Inhibition of translation termination by small molecules targeting ribosomal release factors
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DOI: 10.1038/s41598-019-51977-1
Abstract: The bacterial ribosome is an important drug target for antibiotics that can inhibit different stages of protein synthesis. Among the various classes of compounds that impair translation there are, however, no known small-molecule inhibitors that… read more here.
Keywords: ribosomal release; small molecules; translation; termination ... See more keywords
Mechanisms that ensure speed and fidelity in eukaryotic translation termination
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DOI: 10.1126/science.abi7801
Abstract: How translation stops Protein synthesis concludes when a ribosome encounters a stop codon in a transcript, which triggers the recruitment of highly conserved release factors to liberate the protein product. Lawson et al. used traditional… read more here.
Keywords: release factors; translation; translation termination; termination ... See more keywords