The urinary cortisol metabolome in patients with adrenal insufficiency: Dual-release hydrocortisone is less deleterious than conventional hydrocortisone therapy
Sign Up to like & getrecommendations! Published in 2018 at "Annales d'Endocrinologie"
DOI: 10.1016/j.ando.2018.04.004
Abstract: Introduction Oral once-daily dual-release hydrocortisone (DR-HC) replacement therapy provides a more physiological cortisol profile than conventional thrice-daily (TID) therapy and has demonstrated improved metabolic profile among patients with adrenal insufficiency (AI). The mechanisms by which… read more here.
Keywords: dual release; cortisol; patients adrenal; hydrocortisone ... See more keywords
Modified-release hydrocortisone is associated with lower plasma renin activity in patients with salt-wasting congenital adrenal hyperplasia.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of endocrinology"
DOI: 10.1093/ejendo/lvac006
Abstract: OBJECTIVE Poorly controlled salt-wasting (SW) congenital adrenal hyperplasia (CAH) patients often require high 9α-fluorocortisol doses as they show high levels of 17-hydroxyprogesterone (17OHP), which is a mineralocorticoid (MC)-receptor antagonist. DESIGN We investigated the renin-angiotensin-aldosterone system… read more here.
Keywords: adrenal hyperplasia; modified release; release hydrocortisone; wasting congenital ... See more keywords
SUN-358 Dual Release Hydrocortisone as a New Treatment for Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-sun-358
Abstract: Abstract In patients with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency, long-acting glucocorticoids (GCs) and/or multiple daily dose short-acting GCs are historically suggested to disease management. However, these treatment strategies are generally associated with… read more here.
Keywords: treatment; adrenal hyperplasia; release hydrocortisone; due hydroxylase ... See more keywords
Dual-release hydrocortisone vs conventional glucocorticoids in adrenal insufficiency
Sign Up to like & getrecommendations! Published in 2019 at "Endocrine Connections"
DOI: 10.1530/ec-19-0176
Abstract: Background Dual-release hydrocortisone (DR-HC) improves metabolism in patients with adrenal insufficiency. The aims of this study were to compare the cardiovascular and metabolic effects of conventional glucocorticoids (GCs) vs. DR-HC and of high vs. low… read more here.
Keywords: adrenal insufficiency; release hydrocortisone; conventional glucocorticoids; dual release ... See more keywords
Effects of the therapy shift from cortisone acetate to modified-release hydrocortisone in a group of patients with adrenal insufficiency
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1093838
Abstract: Objective Patients with adrenal insufficiency (AI) may be exposed to supraphysiological glucocorticoids levels during standard treatment with cortisone acetate (CA) or immediate-release hydrocortisone (IR-HC). Recent studies, predominantly including patients in IR-HC treatment, suggested that modified-release… read more here.
Keywords: group; patients adrenal; release hydrocortisone; adrenal insufficiency ... See more keywords