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Synthetic enzyme-based nanoparticles act as smart catalyst for glucose responsive release of insulin.

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0 Published in 2020 at "Journal of biotechnology"

DOI: 10.1016/j.jbiotec.2020.09.023

Abstract: BACKGROUND Earlier studies have attempted to create electronic free insulin delivery systems using different glucose sensing mechanism, no successful clinical translation as hitherto been made. This study aimed to assess the faster responsiveness of the… read more here.

Keywords: insulin; enzyme based; release insulin; based nanoparticles ... See more keywords

Glutaraldehyde crosslinked and alkaline denaturation induced self association of haemoglobin to design nanocarriers for In vitro release of insulin in simulated gastrointestinal fluids (SGFs)

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0 Published in 2018 at "Journal of Drug Delivery Science and Technology"

DOI: 10.1016/j.jddst.2017.12.004

Abstract: Abstract Adopting a novel synthetic route the haemoglobin nanoparticles were prepared by its simultaneous microemulsion mediated crosslinking with glutaraldehyde and alkaline induced denaturation. The as prepared nanoparticles were characterized by techniques like Fourier transform infrared… read more here.

Keywords: insulin; denaturation; insulin simulated; haemoglobin ... See more keywords

Bioresorbable pH- and temperature-responsive injectable hydrogels-incorporating electrosprayed particles for the sustained release of insulin

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0 Published in 2019 at "Polymer Degradation and Stability"

DOI: 10.1016/j.polymdegradstab.2019.02.013

Abstract: Abstract In situ-forming injectable hydrogels are attractive delivery vehicles not only for the controlled delivery of drugs and proteins but also for the controlled the delivery of nanometer sized particles. In this study, pH- and… read more here.

Keywords: temperature responsive; pentablock; release insulin; insulin ... See more keywords

Biocatalytic reversible control of the stiffness of DNA-modified responsive hydrogels: applications in shape-memory, self-healing and autonomous controlled release of insulin†

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0 Published in 2020 at "Chemical Science"

DOI: 10.1039/d0sc01319f

Abstract: The enzymes glucose oxidase (GOx), acetylcholine esterase (AchE) and urease that drive biocatalytic transformations to alter pH, are integrated into pH-responsive DNA-based hydrogels. A two-enzyme-loaded hydrogel composed of GOx/urease or AchE/urease and a three-enzyme-loaded hydrogel… read more here.

Keywords: insulin; dna; shape memory; control stiffness ... See more keywords