Effect of Colonic Absorption on the Pharmacokinetic Properties of Delayed‐Release and Extended‐Release Methylphenidate: In Vivo, In Vitro, and Modeling Evaluations
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DOI: 10.1002/cpdd.1089
Abstract: Most stimulants used to treat attention‐deficit/hyperactivity disorder are administered in the morning and absorbed in the upper gastrointestinal tract. DR/ER‐MPH (formerly HLD200), an evening‐dosed delayed‐release and extended‐release methylphenidate, is predicted to be absorbed in the… read more here.
Keywords: formulation; release; release methylphenidate; extended release ... See more keywords
A Randomized, Phase 3, Double-Blind, Crossover Comparison of Multilayer, Extended-Release Methylphenidate (PRC-063), and Lisdexamfetamine in the Driving Performance of Young Adults With ADHD
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DOI: 10.1177/10870547241226634
Abstract: Objective: To compare PRC-063 (multilayer-release methylphenidate) and lisdexamfetamine dimesylate (LDX) on the driving performance of young adults with attention deficit hyperactivity disorder (ADHD) in a randomized, double-blind, crossover study. Method: Following up to 21 days of… read more here.
Keywords: performance young; prc 063; release methylphenidate; driving performance ... See more keywords
Improvements in Early Morning and Late Afternoon/Evening Functional Impairment with Delayed-Release and Extended-Release Methylphenidate in Children with ADHD: Post Hoc Analysis of 2 Validated Scales by Norm-Referenced Cut-Offs
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DOI: 10.1542/peds.146.1_meetingabstract.592
Abstract: Purpose: In a pivotal phase 3 trial in children (6–12 years) with attention-deficit/hyperactivity disorder (ADHD), evening-dosed HLD200, a delayed-release and extended-release methylphenidate (DR/ER-MPH), significantly improved ADHD symptoms and reduced functional impairment versus placebo (PBO), the… read more here.
Keywords: release extended; release methylphenidate; delayed release; morning ... See more keywords