A click-ready pH-triggered phosphoramidate-based linker for controlled release of monomethyl auristatin E.
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DOI: 10.1016/j.tetlet.2020.152398
Abstract: In this work, we developed a novel "click"-ready pH-cleavable phosphoramidate linker for controlled-release of monomethyl auristantin E (MMAE) in antibody- and small molecule-drug conjugates application. This water-soluble linker was found to have tremendous stability at… read more here.
Keywords: controlled release; linker; release monomethyl; click ready ... See more keywords