Nuclear microRNAs release paused Pol II via the DDX21-CDK9 complex.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2022.110673
Abstract: RNA activation (RNAa) is an uncharacterized mechanism of transcriptional activation mediated by small RNAs, such as microRNAs (miRNAs). A critical issue in RNAa research is that it is difficult to distinguish between changes in gene… read more here.
Keywords: rnaa; paused pol; post transcriptional; transcriptional regulation ... See more keywords
PAF1 regulation of promoter-proximal pause release via enhancer activation
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.aan3269
Abstract: Multitalented enhancers Productive transcription from DNA demands initiation, elongation, and termination. Enhancers are DNA sequences that loop with promoters to initiate transcription. Chen et al. show that enhancers also regulate gene expression by modulating transcription… read more here.
Keywords: promoter proximal; release paused; enhancer activation; paf1 ... See more keywords