Cytokine release syndrome after allogeneic stem cell transplantation with posttransplant cyclophosphamide
Sign Up to like & getrecommendations! Published in 2020 at "Hematological Oncology"
DOI: 10.1002/hon.2772
Abstract: Cytokine release syndrome (CRS) is a systemic inflammatory response with aberrant immune activation and immune hyperstimulation, that leads to increased cytokine levels and inflammation. CRS has been described after antibody and cellular‐based therapies. The use… read more here.
Keywords: cytokine release; crs; hsct; release syndrome ... See more keywords
Management Principles Associated With Cytokine Release Syndrome.
Sign Up to like & getrecommendations! Published in 2019 at "Seminars in oncology nursing"
DOI: 10.1016/j.soncn.2019.08.010
Abstract: OBJECTIVE To discuss current recommendations and resources for nurses to ensure they advocate for patients with cytokine release syndrome (CRS). DATA SOURCES A literature search using key terms: cytokine release syndrome, neurotoxicity, CAR T, adverse… read more here.
Keywords: management; cytokine release; car cell; release syndrome ... See more keywords
Daily ascending dosing in cynomolgus monkeys to mitigate cytokine release syndrome induced by ERY22, surrogate for T-cell redirecting bispecific antibody ERY974 for cancer immunotherapy.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2019.114657
Abstract: CD3 bispecific constructs show promising therapeutic potential as anti-tumor antibodies, but it has concurrently been difficult to manage cytokine release syndrome (CRS) in clinical use. Currently, the most effective measure for reducing CRS is considered… read more here.
Keywords: daily ascending; cynomolgus monkeys; release syndrome; cytokine release ... See more keywords
Targeting JAK-STAT Signaling to Control Cytokine Release Syndrome in COVID-19
Sign Up to like & getrecommendations! Published in 2020 at "Trends in Pharmacological Sciences"
DOI: 10.1016/j.tips.2020.06.007
Abstract: Recent advances in the pathophysiologic understanding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has indicated that patients with severe COVID-19 might experience cytokine release syndrome (CRS), characterized by increased interleukin (IL)-6, IL-2,… read more here.
Keywords: cytokine release; syndrome; release syndrome; targeting jak ... See more keywords
Molecularly Imprinted Polymers with Enzymatic Properties Reduce Cytokine Release Syndrome.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.1c08297
Abstract: A core-shell molecularly imprinted polymer nanoparticle with biological enzyme functional characteristics was developed by oxidative polymerization of template protein and polydopamine on the surface of protease-copper phosphate hybrid nanoflowers by molecular imprinting technology and enzyme… read more here.
Keywords: molecularly imprinted; cytokine release; release syndrome; imprinted polymer ... See more keywords
Extracorporeal cytokine adsorption for treating severe refractory cytokine release syndrome (CRS)
Sign Up to like & getrecommendations! Published in 2020 at "Bone Marrow Transplantation"
DOI: 10.1038/s41409-020-0896-3
Abstract: Immunotherapy is a major breakthrough in cancer management [1]. Currently, immunotherapy with either autologous T cells engineered to express a chimeric antigen receptor (CAR) or with T-cell-engaging bispecific antibody designed to link CD3+ T-cells and… read more here.
Keywords: cytokine adsorption; cytokine release; crs; release syndrome ... See more keywords
Endothelial activation predicts disseminated intravascular coagulopathy, cytokine release syndrome and prognosis in patients treated with anti‐CD19 CAR‐T cells
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Haematology"
DOI: 10.1111/bjh.18596
Abstract: Cytokine release syndrome (CRS) and consumptive coagulopathy can complicate the treatment with chimeric antigen receptor T (CAR‐T) cells. The modified version of the Endothelial Activation and Stress Index (mEASIX), a score derived from haematopoietic stem… read more here.
Keywords: release syndrome; anti cd19; car; car cells ... See more keywords
Cytokine release syndrome‐associated encephalopathy in patients with COVID‐19
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Neurology"
DOI: 10.1111/ene.14491
Abstract: Neurological manifestations in coronavirus disease (COVID)‐2019 may adversely affect clinical outcomes. Severe COVID‐19 and uremia are risk factors for neurological complications. However, the lack of insight into their pathogenesis, particularly with respect to the role… read more here.
Keywords: syndrome associated; cytokine release; associated encephalopathy; release syndrome ... See more keywords
Cytokine release syndrome in severe COVID-19
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.abb8925
Abstract: Lessons from arthritis and cell therapy in cancer patients point to therapy for severe disease In December 2019, a new strain of coronavirus, severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2), was recognized to have emerged in… read more here.
Keywords: cytokine release; coronavirus; covid; release syndrome ... See more keywords
Potential Pathophysiological Mechanisms Underlying Multiple Organ Dysfunction in Cytokine Release Syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Mediators of Inflammation"
DOI: 10.1155/2022/7137900
Abstract: In recent decades, many serious respiratory infections have broken out all over the world, including SARS-CoV, MERS, and COVID-19. They are characterized by strong infectivity, rapid disease progression, high mortality, and poor prognosis. Excessive immune… read more here.
Keywords: cytokine release; release syndrome; multiple organ; organ dysfunction ... See more keywords
A Catecholamine Loop Mediates Cytokine Release Syndrome.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2019-002
Abstract: Catecholamines drives cytokine release syndrome (CRS) in response to bacteria and antitumor agents. read more here.
Keywords: cytokine release; loop mediates; mediates cytokine; release syndrome ... See more keywords