Immune Responsive Release of Tacrolimus to Overcome Organ Transplant Rejection.
Sign Up to like & getrecommendations! Published in 2018 at "Advanced materials"
DOI: 10.1002/adma.201805018
Abstract: Transplant rejection is the key problem in organ transplantation and, in clinic, immunosuppressive agents such as tacrolimus are directly administered to the recipients after surgery for T-cell inhibition. However, direct administration of tacrolimus may bring… read more here.
Keywords: release tacrolimus; responsive release; rejection; immune responsive ... See more keywords
Real-World Study of Once-Daily, Extended-Release Tacrolimus Versus Twice-Daily, Immediate-Release Tacrolimus in Kidney Transplantation: Clinical Outcomes and Healthcare Resource Utilization
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DOI: 10.1007/s12325-019-00904-x
Abstract: IntroductionReal-world data with extended-release tacrolimus (ER-T) are lacking in the USA. This study examined clinical outcomes and healthcare resource utilization in kidney transplant patients receiving ER-T in clinical practice.MethodsThis was a retrospective, single-center analysis (February–June… read more here.
Keywords: outcomes healthcare; healthcare resource; clinical outcomes; release tacrolimus ... See more keywords
Incidence of Posttransplantation Diabetes Mellitus in De Novo Kidney Transplant Recipients Receiving Prolonged-Release Tacrolimus-Based Immunosuppression With 2 Different Corticosteroid Minimization Strategies: ADVANCE, A Randomized Controlled Trial
Sign Up to like & getrecommendations! Published in 2017 at "Transplantation"
DOI: 10.1097/tp.0000000000001453
Abstract: Background ADVANCE (NCT01304836) was a phase 4, multicenter, prospectively randomized, open-label, 24-week study comparing the incidence of posttransplantation diabetes mellitus (PTDM) with 2 prolonged-release tacrolimus corticosteroid minimization regimens. Methods All patients received prolonged-release tacrolimus, basiliximab,… read more here.
Keywords: incidence; release tacrolimus; prolonged release; acute rejection ... See more keywords
Immunosuppression Adherence in Stable Kidney Transplant Patients Converted From Immediate- to Prolonged-Release Tacrolimus in Clinical Practice: A Norwegian Study
Sign Up to like & getrecommendations! Published in 2018 at "Transplantation Direct"
DOI: 10.1097/txd.0000000000000755
Abstract: Background This study investigated medication adherence in kidney transplant patients (KTPs) converted from immediate-release tacrolimus (IR-T) to prolonged-release tacrolimus (PR-T)-based immunosuppression in routine practice. Methods Noninterventional, observational, multicenter study in Norway. Included adult KTPs with… read more here.
Keywords: study; practice; release tacrolimus; tacrolimus ... See more keywords
Efficacy of Prolonged-release Tacrolimus After Conversion From Immediate-release Tacrolimus in Kidney Transplantation: A Retrospective Analysis of Long-term Outcomes From the ADMIRAD Study
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DOI: 10.1097/txd.0000000000001465
Abstract: Background. Prolonged-release tacrolimus (PRT) may offer improved outcomes after kidney transplantation compared with immediate-release tacrolimus (IRT). However, data on outcomes beyond 5-y posttransplantation are lacking. Methods. A retrospective, noninterventional chart review study examined long-term graft… read more here.
Keywords: long term; kidney; release; release tacrolimus ... See more keywords
Two‐year outcomes of low‐exposure extended‐release tacrolimus and mycophenolate mofetil regimen in de novo kidney transplantation: A multi‐center randomized controlled trial
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Transplantation"
DOI: 10.1111/ctr.14655
Abstract: Once‐daily extended‐release tacrolimus (TACER) is commonly administered following kidney transplantation (KTx); however, its optimal dosage remains unknown. read more here.
Keywords: extended release; transplantation; kidney transplantation; release tacrolimus ... See more keywords
Long‐term prolonged‐release tacrolimus outcomes in living donor kidney transplantation: The Japan Academic Consortium of Kidney Transplantation study‐II
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Urology"
DOI: 10.1111/iju.15163
Abstract: To evaluate the 10‐year efficacy and safety of a prolonged‐release tacrolimus‐based combination immunosuppressive regimen on longer‐term outcomes in living donor kidney transplantation. read more here.
Keywords: outcomes living; prolonged release; kidney; kidney transplantation ... See more keywords
Pharmacokinetic Profile of Prolonged-Release Tacrolimus When Administered via Nasogastric Tube in De Novo Liver Transplantation: A Sub-Study of the DIAMOND Trial
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DOI: 10.12659/aot.909693
Abstract: Background For patients unable to swallow during the immediate post-transplant period, immunosuppressant therapy may be initiated by administering prolonged-release tacrolimus as a suspension via a nasogastric tube. Material/Methods In this sub-study of the DIAMOND randomized… read more here.
Keywords: via nasogastric; release tacrolimus; day; tacrolimus ... See more keywords
A Multicenter, Prospective, Observational Study of Conversion from Twice-Daily Immediate-Release to Once-Daily Prolonged-Release Tacrolimus in Liver Transplant Recipients in France: The COBALT Study
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DOI: 10.12659/aot.916041
Abstract: Background In adult liver transplant patients, the use of prolonged-release tacrolimus may have treatment adherence benefits over the immediate-release formulation. The aim of this study was to characterise real-world practice data on conversion of liver… read more here.
Keywords: conversion; release tacrolimus; study; release ... See more keywords
A Prospective, Observational Study of Conversion From Immediate- to Prolonged-Release Tacrolimus in Renal Transplant Recipients in France: The OPALE Study
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DOI: 10.12659/aot.916043
Abstract: Background Potential benefits of once-daily, prolonged-release tacrolimus over the immediate-release formulation include improved adherence to immunosuppressives post transplantation. An observational study was performed to characterize real-world practice surrounding conversion from immediate- to prolonged-release tacrolimus in… read more here.
Keywords: conversion; immediate prolonged; release tacrolimus; study ... See more keywords
Renal Function, Adherence and Quality of Life Improvement After Conversion From Immediate to Prolonged-Release Tacrolimus in Liver Transplantation: Prospective Ten-Year Follow-Up Study
Sign Up to like & getrecommendations! Published in 2022 at "Transplant International"
DOI: 10.3389/ti.2022.10384
Abstract: Immunosuppression non-adherence is a major cause of graft failure after liver transplantation. The aim of this study was to evaluate practice surrounding conversion from immediate-release to prolonged-release Tacrolimus formulation and to assess patient adherence and… read more here.
Keywords: prolonged release; adherence; conversion; release ... See more keywords