Discovery of a novel water-soluble, rapid-release triptolide prodrug with improved drug-like properties and high efficacy in human acute myeloid leukemia.
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DOI: 10.2139/ssrn.4137497
Abstract: In this work, a series of water-soluble triptolide prodrugs were synthesized, and their triptolide release rate, pharmacokinetic characteristics and anti-tumor effect were measured. We found that inserting glycolic acid as a linker between triptolide and… read more here.
Keywords: water; release triptolide; human acute; triptolide prodrug ... See more keywords