Discovery of novel NO-releasing celastrol derivatives with Hsp90 inhibition and cytotoxic activities.
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DOI: 10.1016/j.ejmech.2018.10.013
Abstract: To develop multifunctional drugs, a series of celastrol/NO donor hybrids were designed, synthesized and evaluated. The detection of NO release amounts showed that the more NO of these hybrids released, the more tumor cells were… read more here.
Keywords: inhibition; celastrol derivatives; releasing celastrol; celastrol ... See more keywords