Trypanosoma cruzi Sirtuin 2 as a Relevant Druggable Target: New Inhibitors Developed by Computer-Aided Drug Design
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DOI: 10.3390/ph16030428
Abstract: Trypanosoma cruzi, the etiological agent of Chagas disease, relies on finely coordinated epigenetic regulation during the transition between hosts. Herein we targeted the silent information regulator 2 (Sir2) enzyme, a NAD+-dependent class III histone deacetylase,… read more here.
Keywords: relevant druggable; sirtuin relevant; trypanosoma cruzi; new inhibitors ... See more keywords