The human DNA topoisomerase I mutant Gly717Asp: Higher religation rate is not always associated with camptothecin resistance.
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DOI: 10.1016/j.abb.2019.01.007
Abstract: DNA topoisomerases are key enzyme responsible for modulating the topological state of the DNA by breaking and rejoining of DNA strand. Characterization of a Gly717Asp mutation in the human topoisomerase was performed using several catalytic… read more here.
Keywords: dna; gly717asp; drug; topoisomerase ... See more keywords