Tumors defective in homologous recombination rely on oxidative metabolism: relevance to treatments with PARP inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.201911217
Abstract: Mitochondrial metabolism and the generation of reactive oxygen species (ROS) contribute to the acquisition of DNA mutations and genomic instability in cancer. How genomic instability influences the metabolic capacity of cancer cells is nevertheless poorly… read more here.
Keywords: rely oxidative; parp inhibitors; metabolism; oxidative metabolism ... See more keywords