Comparison of Time to Clinical Improvement With vs Without Remdesivir Treatment in Hospitalized Patients With COVID-19
Sign Up to like & getrecommendations! Published in 2021 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2021.3071
Abstract: Key Points Question Does time to clinical improvement or time to death differ among hospitalized patients treated with vs without remdesivir (alone or with corticosteroids) for coronavirus disease 2019 outside of a clinical trial? Findings… read more here.
Keywords: remdesivir; clinical improvement; hospitalized patients; time clinical ... See more keywords
Remdesivir in Patients With Severe Kidney Dysfunction
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.29236
Abstract: This secondary analysis of a randomized clinical trial examines the risk of kidney or hepatic toxic effects among patients with impaired kidney function at baseline treated with remdesivir. read more here.
Keywords: severe kidney; kidney; kidney dysfunction; patients severe ... See more keywords
Efficacy and safety of remdesivir in hospitalized Covid‐19 patients: Systematic review and meta‐analysis including network meta‐analysis
Sign Up to like & getrecommendations! Published in 2020 at "Reviews in Medical Virology"
DOI: 10.1002/rmv.2187
Abstract: Remdesivir is an antiviral agent that has shown broad‐spectrum activity, including against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Clinical trials investigating the role of remdesivir in coronavirus disease 2019 (Covid‐19) reported conflicting results. This… read more here.
Keywords: covid patients; remdesivir; rate; meta analysis ... See more keywords
Remdesivir bei Patienten mit schwerer COVID-19
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DOI: 10.1007/s00108-020-00800-5
Abstract: Seit der ersten beschriebenen Infektion mit dem „severe acute respiratory syndrome coronavirus 2“ (SARS-CoV-2) im Dezember 2019 hat sich die „coronavirus disease 2019“ (COVID-19) zu einer Pandemie entwickelt, deren Symptomatik vom asymptomatischen Verlauf bis hin… read more here.
Keywords: bei patienten; patienten mit; remdesivir; mit ... See more keywords
Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro
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DOI: 10.1016/j.antiviral.2020.104786
Abstract: An escalating pandemic by the novel SARS-CoV-2 virus is impacting global health and effective therapeutic options are urgently needed. We evaluated the in vitro antiviral effect of compounds that were previously reported to inhibit coronavirus… read more here.
Keywords: inhibit; remdesivir lopinavir; lopinavir emetine; remdesivir ... See more keywords
Remdesivir: Quo vadis?
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DOI: 10.1016/j.bcp.2021.114800
Abstract: Remdesivir (GS-5734, Veklury®) has remained the only antiviral drug formally approved by the US FDA for the treatment of Covid-19 (SARS-CoV-2 infection). Its key structural features are the fact that it is a C-nucleoside (adenosine)… read more here.
Keywords: remdesivir; pharmacology; remdesivir quo; quo vadis ... See more keywords
Safety of Remdesivir in Patients With Acute Kidney Injury or CKD
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DOI: 10.1016/j.ekir.2020.10.005
Abstract: P atients with chronic kidney disease (CKD), especially those with end-stage renal disease (ESRD), are susceptible to the development of severe coronavirus disease 2019 (COVID-19), which is associated with high mortality. Apart from respiratory support… read more here.
Keywords: kidney injury; acute kidney; remdesivir; ckd ... See more keywords
Extracorporeal membrane oxygenation may decrease the plasma concentration of remdesivir in a patient with severe coronavirus disease 2019
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DOI: 10.1016/j.idcr.2021.e01343
Abstract: Remdesivir is an antiviral drug that results in clinical improvement after five days of treatment and accelerates recovery by 31%. No studies have discussed the pharmacokinetic analysis of remdesivir in patients with severe COVID-19 requiring… read more here.
Keywords: extracorporeal membrane; membrane oxygenation; remdesivir; pharmacokinetic analysis ... See more keywords
Treatment with Ivermectin Is Associated with Decreased Mortality in COVID-19 Patients: Analysis of a National Federated Database
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DOI: 10.1016/j.ijid.2021.12.096
Abstract: Purpose To evaluate the difference in mortality of patients treated with ivermectin vs patients treated with remdesivir with COVID-19 in United States using TriNetX Research network, a federated EMR network of over 44 healthcare organizations… read more here.
Keywords: use; ivermectin; remdesivir; covid patients ... See more keywords
Phosphoramidate Prodrugs Continue to Deliver, The Journey of Remdesivir (GS-5734) from RSV to SARS-CoV-2
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DOI: 10.1021/acsmedchemlett.1c00624
Abstract: Remdesivir (GS-5734) is a monophenol, 2-ethylbutylalanine phosphoramidate prodrug of a 1′-cyano-4-aza-7,9-dideazaadenosine C-nucleoside (GS-441524) that is FDA approved for the treatment of hospitalized patients with COVID-19. The prodrug, initially invented for respiratory syncytial virus, was later… read more here.
Keywords: continue deliver; deliver journey; remdesivir 5734; remdesivir ... See more keywords
Phosphoramidate Prodrugs Continue to Deliver: The Journey of Remdesivir (GS-5734) from the Liver to Peripheral Blood Mononuclear Cells.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.2c00105
Abstract: Remdesivir (GS-5734) is a monophenol, 2-ethylbutylalanine phosphoramidate prodrug of GS-441524 that is FDA-approved for the treatment of patients hospitalized for COVID-19. Despite showing strong, broad-spectrum antiviral activity in preclinical models, the clinical efficacy of remdesivir… read more here.
Keywords: remdesivir 5734; phosphoramidate prodrugs; continue deliver; remdesivir ... See more keywords