Considerations and Challenges in the Remdesivir COVID‐19 Pediatric Development Program
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DOI: 10.1002/jcph.2158
Abstract: The US Food and Drug Administration is committed to the development of effective antiviral regimens for pediatric patients with coronavirus disease 2019 (COVID‐19), including infants and neonates. On April 25, 2022, the approved indication of… read more here.
Keywords: covid pediatric; challenges remdesivir; considerations challenges; pediatric development ... See more keywords
Remdesivir and COVID-19 infection, therapeutic benefits or unnecessary risks?
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DOI: 10.1007/s11845-020-02482-2
Abstract: The global COVID-19 pandemic is currently underway. To date, there are about 1.49 million dead and 64.5 million people infected [1]. In this period of global pandemic, several pharmacological treatments have been investigated [2–4]. A… read more here.
Keywords: treatment; covid; sars cov; remdesivir covid ... See more keywords
Why Remdesivir Failed: Preclinical Assumptions Overestimate the Clinical Efficacy of Remdesivir for COVID-19 and Ebola
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DOI: 10.1128/aac.01117-21
Abstract: Remdesivir is a nucleoside monophosphoramidate prodrug that has been FDA approved for coronavirus disease 2019 (COVID-19). However, the clinical efficacy of remdesivir for COVID-19 remains contentious, as several trials have not found statistically significant differences… read more here.
Keywords: efficacy remdesivir; remdesivir covid; remdesivir; clinical efficacy ... See more keywords
Remdesivir for COVID-19: Why Not Dose Higher?
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DOI: 10.1128/aac.02713-20
Abstract: A recent article by Xu et al. in Antimicrob Agents and Chemotherapy examined the on- and off-target toxicity of remdesivir (RDV) and its parent nucleoside, GS-441524 (1).…. read more here.
Keywords: remdesivir covid; remdesivir; dose higher; covid dose ... See more keywords
Hydroxychloroquine and Remdesivir in COVID-19: A critical analysis of recent events.
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DOI: 10.20529/ijme.2020.068
Abstract: The world is going through an unprecedented medical emergency with no effective remedy for the SARS-CoV2 virus causing Covid-19. Two drugs used for other indications in the past, hydroxychloroquine (HCQ) and remdesivir (RDV), are sought… read more here.
Keywords: remdesivir; covid critical; hydroxychloroquine remdesivir; remdesivir covid ... See more keywords
Transient asymptomatic bradycardia and Remdesivir in COVID-19 patients.
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DOI: 10.23736/s0026-4806.22.08035-1
Abstract: BACKGROUND COVID-19 is an infectious disease caused by a coronavirus in humans, namely SARS-CoV-2, which has quickly become a global pandemic. The infection is responsible for a severe form of pneumonia, which may lead to… read more here.
Keywords: bradycardia; bradycardia remdesivir; remdesivir; asymptomatic bradycardia ... See more keywords
Mortality Benefit of Remdesivir in COVID-19: A Systematic Review and Meta-Analysis
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DOI: 10.3389/fmed.2020.606429
Abstract: Importance/Background: During current public health emergency of COVID-19 pandemic, repurposing of existing antiviral drugs may be an efficient strategy since there is no proven effective treatment. Published literature shows Remdesivir has broad-spectrum antiviral activity against… read more here.
Keywords: remdesivir; remdesivir covid; meta analysis; mortality ... See more keywords