Comparison of pregabalin with magnesium sulfate in the prevention of remifentanil‐induced hyperalgesia in patients undergoing rhinoplasty: A randomized clinical trial
Sign Up to like & getrecommendations! Published in 2022 at "Laryngoscope Investigative Otolaryngology"
DOI: 10.1002/lio2.905
Abstract: Remifentanil is usually used for controlled hypotension during rhinoplasty under general anesthesia (G/A). One of the complications of the remifentanil is postoperative hyperalgesia. In this study, we compare the effectiveness of pregabalin with that of… read more here.
Keywords: remifentanil; prevention; induced hyperalgesia; remifentanil induced ... See more keywords
A Role for Transmembrane Protein 16C/Slack Impairment in Excitatory Nociceptive Synaptic Plasticity in the Pathogenesis of Remifentanil-induced Hyperalgesia in Rats.
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience bulletin"
DOI: 10.1007/s12264-021-00652-5
Abstract: Remifentanil is widely used to control intraoperative pain. However, its analgesic effect is limited by the generation of postoperative hyperalgesia. In this study, we investigated whether the impairment of transmembrane protein 16C (TMEM16C)/Slack is required… read more here.
Keywords: remifentanil; hyperalgesia; slack; remifentanil induced ... See more keywords
TRPV1 and spinal astrocyte activation contribute to remifentanil-induced hyperalgesia in rats.
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DOI: 10.1097/wnr.0000000000001329
Abstract: Remifentanil is an ultra-short-acting µ-opioid receptor agonist, which is widely used in general anesthesia. However, comparing with other opioids, remifentanil often induces hyperalgesia. Accumulating evidence suggests that the transient receptor potential (TRP) channels and glial… read more here.
Keywords: activation; remifentanil; remifentanil induced; induced hyperalgesia ... See more keywords
KCC2 receptor upregulation potentiates antinociceptive effect of GABAAR agonist on remifentanil-induced hyperalgesia
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DOI: 10.1177/17448069221082880
Abstract: GABAergic system disinhibition played an important role in the pathogenesis of remifentanil-induced hyperalgesia (RIH). K+-Cl--cotransporter-2 (KCC2) has the potential to enhance the strength of GABAergic signaling function. However, few reports have focused on the additive… read more here.
Keywords: gaba; remifentanil induced; rih; kcc2 ... See more keywords
TLR4 signaling pathway in sensory neurons mediates remifentanil-induced postoperative hyperalgesia via TRPA1.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular pain"
DOI: 10.1177/17448069231158290
Abstract: BACKGROUND Remifentanil-induced postoperative hyperalgesia (RIH) refers to a state of hyperalgesia or aggravated pre-existing pain after remifentanil exposure. There has been considerable interest in understanding and preventing RIH. However, the mechanisms responsible for RIH are… read more here.
Keywords: trpa1; tlr4 signaling; hyperalgesia; rih ... See more keywords