Germline variants in SMARCB1 and other members of the BAF chromatin-remodeling complex across human disease entities: a meta-analysis
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Human Genetics"
DOI: 10.1038/s41431-018-0143-1
Abstract: Germline variants that affect function are found in seven genes of the BAF chromatin-remodeling complex. They are linked to a broad range of diseases that, according to the gene affected, range from non-syndromic or syndromic… read more here.
Keywords: chromatin remodeling; remodeling complex; disease; germline ... See more keywords
Divergent regulatory roles of NuRD chromatin remodeling complex subunits GATAD2 and CHD4 in Caenorhabditis elegans.
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DOI: 10.1093/genetics/iyac046
Abstract: During proteotoxic stress, a pathway known as the heat shock response (HSR) is induced to maintain protein-folding homeostasis, or proteostasis. Previously, we identified the Caenorhabditis elegans GATAD2 ortholog, dcp-66, as a novel regulator of the… read more here.
Keywords: remodeling complex; caenorhabditis elegans; nurd subunits; nurd chromatin ... See more keywords
The ACF chromatin-remodeling complex is essential for Polycomb repression
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DOI: 10.7554/elife.77595
Abstract: Establishing and maintaining appropriate gene repression is critical for the health and development of multicellular organisms. Histone H3 lysine 27 (H3K27) methylation is a chromatin modification associated with repressed facultative heterochromatin, but the mechanism of… read more here.
Keywords: remodeling complex; acf chromatin; repression; polycomb repression ... See more keywords