Nitrite treatment downregulates vascular MMP‐2 activity and inhibits vascular remodeling in hypertension independently of its antihypertensive effects
Sign Up to like & getrecommendations! Published in 2019 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.11.002
Abstract: ABSTRACT Hypertension is associated with cardiovascular remodeling. Given that impaired redox state activates matrix metalloproteinase (MMP)− 2 and promotes vascular remodeling, we hypothesized that nitrite treatment at a non‐antihypertensive dose exerts antioxidant effects and attenuates… read more here.
Keywords: remodeling hypertension; vascular mmp; vascular remodeling; hypertension ... See more keywords
RNF34 ablation promotes cerebrovascular remodeling and hypertension by increasing NADPH-derived ROS generation
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2021.105396
Abstract: Cerebrovascular remodeling is the most common cause of hypertension and stroke. Ubiquitin E3 ligase RING finger protein 34 (RNF34) is suggested to be associated with the development of multiple neurological diseases. However, the importance of… read more here.
Keywords: remodeling hypertension; rnf34; ros generation; derived ros ... See more keywords
The Molecular Mechanism of Aerobic Exercise Improving Vascular Remodeling in Hypertension
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.792292
Abstract: The treatment and prevention of hypertension has been a worldwide medical challenge. The key pathological hallmark of hypertension is altered arterial vascular structure and function, i.e., increased peripheral vascular resistance due to vascular remodeling. The… read more here.
Keywords: aerobic exercise; molecular mechanism; remodeling hypertension; vascular remodeling ... See more keywords