DLX2 Is a Potential Immune-Related Prognostic Indicator Associated with Remodeling of Tumor Microenvironment in Lung Squamous Cell Carcinoma: An Integrated Bioinformatical Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/6512300
Abstract: Background It is still an unmet clinical need to identify potent biomarkers for immunotherapy on patients with lung squamous cell carcinoma (LUSC). Methods In this study, we explored the differentially expressed genes (DEGs) that were… read more here.
Keywords: cell; remodeling tumor; tumor microenvironment; dlx2 ... See more keywords
Pilot Study of ONCOS-102 and Pembrolizumab: Remodeling of the Tumor Microenvironment and Clinical Outcomes in Anti–PD-1–Resistant Advanced Melanoma
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DOI: 10.1158/1078-0432.ccr-22-2046
Abstract: Abstract Purpose: Intratumoral oncolytic virotherapy may overcome anti–PD(L)-1 resistance by triggering pro-inflammatory remodeling of the tumor microenvironment. This pilot study investigated ONCOS-102 (oncolytic adenovirus expressing GM-CSF) plus anti–programmed cell death protein 1 (PD)-1 therapy in… read more here.
Keywords: advanced melanoma; remodeling tumor; anti resistant; oncos 102 ... See more keywords
Remodeling tumor-associated macrophages with a CD47xMesothelin bispecific antibody for efficient elimination of solid tumor cells.
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DOI: 10.1200/jco.2018.36.15_suppl.e15126
Abstract: e15126Background: Mesothelin (MSLN) is a cell surface glycoprotein associated with poor prognosis in many cancers, with elevated soluble MSLN (sMSLN) serum levels considered a biomarker of disease ... read more here.
Keywords: tumor associated; remodeling tumor; macrophages cd47xmesothelin; associated macrophages ... See more keywords
Remodeling the tumor immune microenvironment with oncolytic viruses expressing miRNAs
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DOI: 10.3389/fimmu.2022.1071223
Abstract: MiRNAs (miRNA, miR) play important functions in the tumor microenvironment (TME) by silencing gene expression through RNA interference. They are involved in regulating both tumor progression and tumor suppression. The pathways involved in miRNA processing… read more here.
Keywords: microenvironment oncolytic; remodeling tumor; immune microenvironment; tumor immune ... See more keywords
Role of microRNAs in remodeling the tumor microenvironment (Review)
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DOI: 10.3892/ijo.2019.4952
Abstract: MicroRNAs (miRNAs) are short non-coding RNAs that are known to regulate gene expression at the post-transcriptional level. miRNA expression is often deregulated in several human cancers, affecting the communication between tumor stroma and tumor cells,… read more here.
Keywords: tumor; remodeling tumor; review; tumor microenvironment ... See more keywords