Abstract PR002: Hypoxia-induced epigenetic changes coordinate transcription start site selection and translational control through remodeling of 5’UTRs
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DOI: 10.1158/1538-8514.rnadrivers24-pr002
Abstract: Adaptation to hypoxia enhances cancer cell malignancy and negatively impacts patient outcomes. Reprogramming of mRNA translation is an essential component of the hypoxia-adaptive response. During hypoxia, cells undergo a global decrease in protein synthesis. However,… read more here.
Keywords: cancer; transcription start; remodeling utrs; hypoxia ... See more keywords