Exploiting vulnerabilities of SWI/SNF chromatin remodelling complexes for cancer therapy
Sign Up to like & getrecommendations! Published in 2021 at "Oncogene"
DOI: 10.1038/s41388-021-01781-x
Abstract: Multi-subunit ATPase-dependent chromatin remodelling complexes SWI/SNF (switch/sucrose non-fermentable) are fundamental epigenetic regulators of gene transcription. Functional genomic studies revealed a remarkable mutation prevalence of SWI/SNF-encoding genes in 20–25% of all human cancers, frequently driving oncogenic… read more here.
Keywords: chromatin remodelling; chromatin; snf chromatin; remodelling complexes ... See more keywords
H2A.Z and chromatin remodelling complexes: a focus on fungi
Sign Up to like & getrecommendations! Published in 2020 at "Critical Reviews in Microbiology"
DOI: 10.1080/1040841x.2020.1781784
Abstract: Abstract Chromatin is a highly dynamic structure that closely relates with gene expression in eukaryotes. ATP-dependent chromatin remodelling, histone post-translational modification and DNA methylation are the main ways that mediate such plasticity. The histone variant… read more here.
Keywords: chromatin; chromatin remodelling; complexes focus; remodelling complexes ... See more keywords