A new purified Lawsoniaside remodels amyloid-β42 fibrillation into a less toxic and non-amyloidogenic pathway.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.04.005
Abstract: Mounting evidence indicates soluble Aβ42 oligomers as the most toxic species causing neuronal death which leads to the onset and progression of Alzheimer disease (AD). Recently, it has been found that neurotoxic Aβ42 oligomers grow… read more here.
Keywords: amyloid fibrillation; purified lawsoniaside; remodels amyloid; new purified ... See more keywords
Phosphorylation remodels amyloid
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.369.6507.1070-c
Abstract: Structural Biology Abnormal aggregation of the protein α-synuclein (α-syn) is a hallmark of Parkinson's disease (PD) and several other neurodegenerative disorders. Disease-associated α-syn amyloid fibrils accumulate in Lewy bodies and are often phosphorylated. Phosphorylation at… read more here.
Keywords: remodels amyloid; biology; structure; phosphorylation remodels ... See more keywords