Partially oxidized DJ-1 inhibits α-synuclein nucleation and remodels mature α-synuclein fibrils in vitro
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DOI: 10.1038/s42003-019-0644-7
Abstract: DJ-1 is a deglycase enzyme which exhibits a redox-sensitive chaperone-like activity. The partially oxidized state of DJ-1 is active in inhibiting the aggregation of α-synuclein, a key protein associated with Parkinson’s disease. The underlying molecular mechanism… read more here.
Keywords: aggregation; synuclein; remodels mature; partially oxidized ... See more keywords