Remote Functionalization through Symmetric or Asymmetric Substitutions Control the Pathway of Intermolecular Singlet Fission.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of chemical theory and computation"
DOI: 10.1021/acs.jctc.9b00419
Abstract: Singlet fission (SF) produces two coupled triplet excitons from a high energy singlet excitation. The mechanism of SF in a variety of phenyl (-Ph) substituted pentacene is systematically studied through both ab initio and density… read more here.
Keywords: state; singlet fission; active space; remote functionalization ... See more keywords
Radical Alkene-Trifluoromethylation-Triggered Nitrile Insertion/Remote Functionalization Relay Processes: Diverse Synthesis of Trifluoromethylated Azaheterocycles Enabled by Copper Catalysis.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00083
Abstract: A copper-catalyzed alkene-trifluoromethylation-triggered nitrile insertion/remote functionalization relay process has been achieved, in which "interrupted" remote 1,n-difunctionalizations of alkenes with nitrile insertion can deliver iminyl radical intermediates instead of C-based radicals, followed by subsequent 1,n-HAT to… read more here.
Keywords: remote functionalization; nitrile insertion; functionalization relay;
Regiodivergent Remote C-H Functionalization by Tuning Template Geometry.
Sign Up to like & getrecommendations! Published in 2024 at "Organic letters"
DOI: 10.1021/acs.orglett.4c01460
Abstract: For transition-metal-catalyzed C-H functionalization, precise differentiation between remote adjacent C(sp2)-H bonds remains a long-standing challenge. Here, the template structure-directivity relationship on remote C-H functionalization of arenes was experimentally and computationally studied. By using geometry-tunable templates,… read more here.
Keywords: regiodivergent remote; remote functionalization; tuning template; functionalization ... See more keywords
Remote Functionalization of Inert C(sp3)-H Bonds via Dual Catalysis Driven by Alkene Hydrofluoroalkylation Using Industrial Feedstocks.
Sign Up to like & getrecommendations! Published in 2024 at "Organic letters"
DOI: 10.1021/acs.orglett.4c02901
Abstract: We have developed a dual-catalytic system capable of site-selective azidation of inert C(sp3)-H bonds with concomitant and modular anti-Markovnikov alkene fluoroalkylation. The protocol leverages the synergetic cooperation of both the photocatalyst and earth-abundant iron catalyst… read more here.
Keywords: bonds via; remote functionalization; functionalization inert; sp3 bonds ... See more keywords
Remote Functionalization by Pd-Catalyzed Isomerization of Alkynyl Alcohols
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.4c05136
Abstract: In recent years, progress has been made in the development of catalytic methods that allow remote functionalizations based on alkene isomerization. In contrast, protocols based on alkyne isomerization are comparatively rare. Herein, we report a… read more here.
Keywords: remote functionalization; alkynyl alcohols; isomerization alkynyl; isomerization ... See more keywords
Three-component ruthenium-catalyzed remote C-H functionalization of 8-aminoquinoline amides.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc05491g
Abstract: Multicomponent reactions can efficiently construct complex molecular structures from simple precursors. Herein, a novel ruthenium-catalyzed three-component highly selective remote C-H functionalization of 8-aminoquinoline amides has been described. The reaction tolerates a wide range of functional… read more here.
Keywords: functionalization aminoquinoline; remote functionalization; aminoquinoline amides; three component ... See more keywords
Novel Strategies in C-H Oxidations for Natural Product Diversification—A Remote Functionalization Application Summary
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2021.737530
Abstract: Selectively activating the distal inactive C-H bond for functionalization is one of the on-going challenge in organic synthetic chemistry. In recent years, benefiting from the development of selective synthesis methods, novel methodologies not only make… read more here.
Keywords: chemistry; remote functionalization; natural product; functionalization ... See more keywords
Brønsted acid catalyzed remote C6 functionalization of 2,3-disubstituted indoles with β,γ-unsaturated α-ketoester
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.992398
Abstract: Graphical Abstract A metal-free catalytic approach for the remote C6-functionalization of 2,3-disubstituted indoles has been developed. In the presence of catalytic amounts of Brønsted acid, the β,γ-unsaturated α-ketoesters react with 2,3-disubstituted indoles at the C6… read more here.
Keywords: remote functionalization; functionalization disubstituted; disubstituted indoles; nsted acid ... See more keywords