Enantioselective Remote C(sp3)-H Cyanation via Dual Photoredox and Copper Catalysis.
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DOI: 10.1021/acs.orglett.0c02008
Abstract: The remote C(sp3)-H cyanation of carboxamides has been described by merging photoredox and copper catalysis in a site-selective and enantiocontrolled manner. The protocol is the integration of photoinduced and nitrogen-centered radical-mediated intermolecular hydrogen atom transfer… read more here.
Keywords: remote sp3; copper; cyanation; sp3 cyanation ... See more keywords
Thioether-Directed NiH-Catalyzed Remote γ-C(sp3)-H Hydroamidation of Alkenes by 1,4,2-Dioxazol-5-ones.
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DOI: 10.1021/jacs.1c05834
Abstract: A NiH-catalyzed thioether-directed cyclometalation strategy is developed to enable remote methylene C-H bond amidation of unactivated alkenes. Due to the preference for five-membered nickelacycle formation, the chain-walking isomerization initiated by the NiH insertion to an… read more here.
Keywords: directed nih; remote sp3; catalyzed remote; thioether directed ... See more keywords
Copper-catalyzed remote C(sp3)–H azidation and oxidative trifluoromethylation of benzohydrazides
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DOI: 10.1038/s41467-019-08741-w
Abstract: The Hofmann-Löffler-Freytag (HLF) reaction is a prototypical example of radical-based remote functionalization of unactivated C(sp3)–H bond. While 1,5-hydrogen atom transfer (1,5-HAT) of the amidyl radical is thermodynamically favorable and is well-established, the method for the… read more here.
Keywords: trifluoromethylation; remote sp3; azidation oxidative; oxidative trifluoromethylation ... See more keywords
Photoredox-mediated remote C(sp3)–H heteroarylation of free alcohols† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc04134b
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Science"
DOI: 10.1039/c8sc04134b
Abstract: We report an efficient and economical method for remote δ C(sp3)–H heteroarylation of free aliphatic alcohols using a hypervalent iodine PFBI-OH oxidant under photoredox catalysis. read more here.
Keywords: remote sp3; sp3 heteroarylation; heteroarylation free; photoredox mediated ... See more keywords