Remyelination in humans due to a retinoid‐X receptor agonist is age‐dependent
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DOI: 10.1002/acn3.51595
Abstract: Remyelination efficiency declines with advancing age in animal models, but this has been harder to demonstrate in people with multiple sclerosis. We show that bexarotene, a putatively remyelinating retinoid‐X receptor agonist, shortened the visual evoked… read more here.
Keywords: remyelination; age; retinoid receptor; remyelination humans ... See more keywords
Berberine enhances L1 expression and axonal remyelination in rats after brachial plexus root avulsion
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DOI: 10.1002/brb3.1792
Abstract: Enhanced remyelination of the regenerated axons results in functional re‐innervation and improved functional motor recovery after brachial plexus root avulsion (BPRA). The neural cell adhesion molecule L1 (L1CAM, L1) regulates myelination and promotes regeneration after… read more here.
Keywords: root avulsion; remyelination; axonal remyelination; plexus root ... See more keywords
MMP7 cleaves remyelination‐impairing fibronectin aggregates and its expression is reduced in chronic multiple sclerosis lesions
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DOI: 10.1002/glia.23328
Abstract: Upon demyelination, transient expression of fibronectin precedes successful remyelination. However, in chronic demyelination observed in multiple sclerosis (MS), aggregates of fibronectin persist and contribute to remyelination failure. Accordingly, removing fibronectin (aggregates) would constitute an effective… read more here.
Keywords: remyelination; fibronectin; mmp7 cleaves; multiple sclerosis ... See more keywords
Overexpression of P2X4 receptor in Schwann cells promotes motor and sensory functional recovery and remyelination via BDNF secretion after nerve injury
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DOI: 10.1002/glia.23527
Abstract: Of the seven P2X receptor subtypes, P2X4 receptor (P2X4R) is widely distributed in the central nervous system, including in neurons, astrocytes, and microglia. Accumulating evidence supports roles for P2X4R in the central nervous system, including… read more here.
Keywords: schwann; schwann cells; remyelination; p2x4r ... See more keywords
The guanine nucleotide exchange factor Vav3 modulates oligodendrocyte precursor differentiation and supports remyelination in white matter lesions
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DOI: 10.1002/glia.23548
Abstract: The tightly controlled processes of myelination and remyelination require the participation of the cytoskeleton. The reorganization of the cytoskeleton is controlled by small GTPases of the RhoA family. Here, we report that Vav3, a Rho… read more here.
Keywords: guanine nucleotide; nucleotide exchange; remyelination; exchange factor ... See more keywords
The formation of a glial scar does not prohibit remyelination in an animal model of multiple sclerosis
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DOI: 10.1002/glia.23556
Abstract: The role of astrocytes in the pathophysiology of multiple sclerosis (MS) is discussed controversially. Especially the formation of the glial scar is often believed to act as a barrier for remyelination. At the same time,… read more here.
Keywords: remyelination; glial scar; multiple sclerosis; animal model ... See more keywords
The K2P‐channel TASK1 affects Oligodendroglial differentiation but not myelin restoration
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DOI: 10.1002/glia.23577
Abstract: In multiple sclerosis, demyelination occurs as a consequence of chronic autoimmunity in the central nervous system causing progressive neurological impairment in patients. After a demyelinating event, new myelin sheaths are formed by adult oligodendroglial progenitor… read more here.
Keywords: remyelination; task1; k2p channel; differentiation ... See more keywords
ErbB receptor signaling directly controls oligodendrocyte progenitor cell transformation and spontaneous remyelination after spinal cord injury
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DOI: 10.1002/glia.23586
Abstract: We recently discovered a novel role for neuregulin‐1 (Nrg1) signaling in mediating spontaneous regenerative processes and functional repair after spinal cord injury (SCI). We revealed that Nrg1 is the molecular signal responsible for spontaneous functional… read more here.
Keywords: remyelination; transformation; erbb; receptor ... See more keywords
Dimethylarginine dimethylaminohydrolase 1 as a novel regulator of oligodendrocyte differentiation in the central nervous system remyelination
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DOI: 10.1002/glia.24060
Abstract: Remyelination is a regenerative process that restores the lost neurological function and partially depends on oligodendrocyte differentiation. Differentiation of oligodendrocytes spontaneously occurs after demyelination, depending on the cell intrinsic mechanisms. By combining a loss‐of‐function genomic… read more here.
Keywords: oligodendrocyte differentiation; remyelination; novel regulator; differentiation ... See more keywords
Monocytes in central nervous system remyelination.
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DOI: 10.1002/glia.24111
Abstract: Remyelination failure with aging and progression of neurodegenerative disorders contributes to axonal dysfunction, highlighting the importance of understanding the mechanisms underpinning this process to develop regenerative therapies. Central nervous system (CNS) macrophages, encompassing both resident… read more here.
Keywords: monocytes central; remyelination; nervous system; central nervous ... See more keywords
The orphan G protein‐coupled receptor GPR149 is a negative regulator of myelination and remyelination
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DOI: 10.1002/glia.24233
Abstract: Myelin sheath, formed by oligodendrocytes (OLs) in the central nervous system (CNS) and Schwann cells in periphery, plays a critical role in supporting neuronal functions. OLs, differentiated from oligodendrocyte precursor cells (OPCs), are important for… read more here.
Keywords: orphan protein; remyelination; gpr149; myelination ... See more keywords