Germline mutations of renal cancer predisposition genes and clinical relevance in Chinese patients with sporadic, early‐onset disease
Sign Up to like & getrecommendations! Published in 2019 at "Cancer"
DOI: 10.1002/cncr.31908
Abstract: An inherited susceptibility to renal cancers is associated with multiple predisposing genes, but most screening tests are limited to patients with a family history. Next‐generation sequencing (NGS)–based multigene panels provide an efficient and adaptable tool… read more here.
Keywords: mutations renal; cancer predisposition; germline; germline mutations ... See more keywords
Higher genetically predicted low-density lipoprotein levels increase the renal cancer risk independent of triglycerides and high-density lipoprotein levels: a Mendelian randomization study.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of cancer"
DOI: 10.1002/ijc.34032
Abstract: The causation between lipids and renal cancer remains inconclusive. Our purpose is to explore the causal relationships between the three primary lipid metabolism-related substances, namely triglycerides (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) with… read more here.
Keywords: lipoprotein levels; density lipoprotein; renal cancer; cancer ... See more keywords
Deubiquitinase USP9X loss sensitizes renal cancer cells to mTOR inhibition.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of cancer"
DOI: 10.1002/ijc.34575
Abstract: Mammalian target of rapamycin (mTOR) is a central regulator of mammalian metabolism and physiology. Aberrant hyperactivation of the mTOR pathway promotes tumor growth and metastasis, and can also promote tumor resistance to chemotherapy and cancer… read more here.
Keywords: renal cancer; inhibition; sensitivity; mtor inhibitors ... See more keywords
Value of Contrast‐Enhanced Ultrasound in the Diagnosis of Renal Cancer and in Comparison With Contrast‐Enhanced Computed Tomography: A Meta‐analysis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Ultrasound in Medicine"
DOI: 10.1002/jum.14769
Abstract: The purpose of this meta‐analysis was to assess the diagnostic accuracy of contrast‐enhanced ultrasound (CEUS) in renal cancer and to compare it with contrast‐enhanced computed tomography (CECT). read more here.
Keywords: contrast; meta analysis; enhanced ultrasound; contrast enhanced ... See more keywords
The Classification of Renal Cancer in 3-Phase CT Images Using a Deep Learning Method
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Digital Imaging"
DOI: 10.1007/s10278-019-00230-2
Abstract: In this research, we exploit an image-based deep learning framework to distinguish three major subtypes of renal cell carcinoma (clear cell, papillary, and chromophobe) using images acquired with computed tomography (CT). A biopsy-proven benchmarking dataset… read more here.
Keywords: phase; deep learning; learning method; cell ... See more keywords
Intratumoral submicron particle docetaxel inhibits syngeneic Renca renal cancer growth and increases CD4+, CD8+, and Treg levels in peripheral blood
Sign Up to like & getrecommendations! Published in 2020 at "Investigational New Drugs"
DOI: 10.1007/s10637-020-00922-5
Abstract: Administration of chemotherapeutics as direct injections into tumors offers increased anti-tumor activity and reduced systemic toxicity. In this study, the Renca syngeneic murine xenograft model of renal cancer was used to evaluate the effects of… read more here.
Keywords: submicron particle; tumor; particle docetaxel; intratumoral submicron ... See more keywords
High expression of TAZ serves as a novel prognostic biomarker and drives cancer progression in renal cancer
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2019.02.001
Abstract: &NA; Renal cell carcinomas are a group of most common renal malignancies whose clinical intervention is complicated by the lack of early diagnosis and reliable prognosis biomarkers, insensitive radiotherapy and chemotherapy and expensive molecular‐targeted drugs.… read more here.
Keywords: taz; taz expression; cancer; cell ... See more keywords
Englerin A Rewires Phosphosignaling via Hsp27 Hyperphosphorylation to Induce Cytotoxicity in Renal Cancer Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.2c00248
Abstract: Englerin A (EA) is a small-molecule natural product with selective cytotoxicity against renal cancer cells. EA has been shown to induce apoptosis and cell death through cell-cycle arrest and/or insulin signaling pathways. However, its biological… read more here.
Keywords: renal cancer; upon treatment; cancer; cytotoxicity renal ... See more keywords
Analysis of renal cancer cell lines from two major resources enables genomics-guided cell line selection
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms15165
Abstract: The utility of cancer cell lines is affected by the similarity to endogenous tumour cells. Here we compare genomic data from 65 kidney-derived cell lines from the Cancer Cell Line Encyclopedia and the COSMIC Cell… read more here.
Keywords: kidney; cell lines; cancer cell; cell ... See more keywords
Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-14700-7
Abstract: Current treatments for clear cell renal cell cancer (ccRCC) are insufficient because two-thirds of patients with metastases progress within two years. Here we report the identification and characterization of a cancer stem cell (CSC) population… read more here.
Keywords: cancer stem; wnt notch; cancer; stem ... See more keywords
Anti-proliferative and anti-migratory properties of coffee diterpenes kahweol acetate and cafestol in human renal cancer cells
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-020-80302-4
Abstract: Despite improvements in systemic therapy options for renal cancer, it remains one of the most drug-resistant malignancies. Interestingly, reports have shown that kahweol and cafestol, natural diterpenes extracted from coffee beans, exhibit anti-cancer activity. However,… read more here.
Keywords: acetate cafestol; cafestol human; kahweol acetate; renal cancer ... See more keywords