The histone deacetylases HDAC1 and HDAC2 are required for the growth and survival of renal carcinoma cells
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Toxicology"
DOI: 10.1007/s00204-018-2229-5
Abstract: Novel therapies are required for the treatment of metastatic renal cell carcinoma (RCC), which is associated with inoperable disease and patient death. Histone deacetylases (HDACs) are epigenetic modifiers and potential drug targets. Additional information on… read more here.
Keywords: carcinoma; deacetylases hdac1; histone deacetylases; renal carcinoma ... See more keywords
JS-K, a GST-activated nitric oxide donor prodrug, enhances chemo-sensitivity in renal carcinoma cells and prevents cardiac myocytes toxicity induced by Doxorubicin
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-017-3359-9
Abstract: PurposeDoxorubicin, a highly effective and widely used anthracycline antibiotic in multiple chemotherapy regimens, has been limited by its cardiotoxicity. The aim of this study is to investigate the effect of nitric oxide donor prodrug JS-K… read more here.
Keywords: cardiac myocytes; carcinoma; apoptosis; toxicity ... See more keywords
Establishment of a bioluminescent Renca cell line for renal carcinoma research
Sign Up to like & getrecommendations! Published in 2017 at "International Urology and Nephrology"
DOI: 10.1007/s11255-017-1707-7
Abstract: PurposeLuciferase modification of tumour cells enables early and non-invasive imaging to detect tumour growth in situ and could provide sensitive and effective detection of carcinoma during research and therapy.MethodsRenca cells, a murine renal carcinoma cell… read more here.
Keywords: renca; carcinoma; carcinoma research; renca luc ... See more keywords
Physical Model of Clear‐Cell Renal Carcinoma With Inferior Vena Cava Extension Created From a 3‐Dimensional Printer to Aid in Surgical Resection: A Case Report
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Genitourinary Cancer"
DOI: 10.1016/j.clgc.2017.04.025
Abstract: Introduction The use of 3-dimensional (3D) models in preoperative planning, surgical approach, and surgical education for urological practices is in its infancy.Notonly can3Dmodels be of use to physicians, but 3Dmodels can also help patients understandphysiology,… read more here.
Keywords: cell renal; vena cava; inferior vena; renal carcinoma ... See more keywords
A case report of one of the largest (9900 cm3) clear cell renal carcinoma removed in Asia
Sign Up to like & getrecommendations! Published in 2020 at "Urology Case Reports"
DOI: 10.1016/j.eucr.2020.101208
Abstract: Introduction Giant renal cell carcinoma (volume more than 1000 cc) is a rare case. Management included surgical resection combined with targeted therapy. Case presentation We reported a case of giant clear cell renal carcinoma with… read more here.
Keywords: cell renal; case; renal carcinoma; cell ... See more keywords
Loss of SWI/SNF complex expression in undifferentiated renal carcinoma in acquired cystic kidney
Sign Up to like & getrecommendations! Published in 2018 at "Pathology International"
DOI: 10.1111/pin.12671
Abstract: To the Editor: Loss of the SWI/SNF complex has recently been reported in carcinomas of various organs, including stomach, kidneys, upper urinary tract, and the lung. These carcinomas exhibited similar morphology, undifferentiated pleomorphic or rhabdoid… read more here.
Keywords: carcinoma; renal carcinoma; snf complex; swi snf ... See more keywords
WT1 Inhibits Human Renal Carcinoma Cell Proliferation and Induces G2/M Arrest by Upregulating IL-24 Expression
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/1093945
Abstract: The transcription factor Wilms' tumor 1 (WT1) is involved in development, tissue homeostasis, and disease. However, the exact roles and the mechanisms of WT1 in renal carcinoma are not well understood. Therefore, in this study,… read more here.
Keywords: cell; proliferation; expression; renal carcinoma ... See more keywords
Inhibitory Effect of Ursolic Acid on Proliferation and Migration of Renal Carcinoma Cells and Its Mechanism
Sign Up to like & getrecommendations! Published in 2022 at "Computational Intelligence and Neuroscience"
DOI: 10.1155/2022/1529132
Abstract: Background Renal carcinoma is one of the most common malignant tumors in the urinary system. Autophagy can be both activated and inhibited in renal carcinoma, and it plays a double-edged role in the development of… read more here.
Keywords: ursolic acid; renal carcinoma; effect; 786 cells ... See more keywords
Rac Signaling Drives Clear Cell Renal Carcinoma Tumor Growth by Priming the Tumor Microenvironment for an Angiogenic Switch
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-19-0762
Abstract: Clear cell renal cell carcinoma (ccRCC) remains a common cause of cancer mortality. Better understanding of ccRCC molecular drivers resulted in the development of antiangiogenic therapies that block the blood vessels that supply tumors with… read more here.
Keywords: growth; carcinoma; clear cell; renal carcinoma ... See more keywords
FAST1 Predicts Poor Survival of Renal Carcinoma and Promotes Its Progression Through the TGF-β/Smad Pathway
Sign Up to like & getrecommendations! Published in 2021 at "OncoTargets and therapy"
DOI: 10.2147/ott.s288847
Abstract: Purpose Renal carcinoma (RC) originates in the renal tubular epithelial system, among which renal cell carcinoma (RCC) is the most frequent one. The forkhead activin signal transducer 1 (FAST1) has been shown to interfere with… read more here.
Keywords: fast1; tgf smad; smad pathway; renal carcinoma ... See more keywords
Role of Nivolumab in the Modulation of PD-1 and PD-L1 Expression in Papillary and Clear Cell Renal Carcinoma (RCC)
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10123244
Abstract: The expression and cellular mechanisms of programmed cell death-1 protein (PD-1) and its ligands (PD-L1 and PD-L2) in renal cancer cells are not well known. Here, we aimed to investigate the response of renal carcinoma… read more here.
Keywords: cell; rcc; expression; renal carcinoma ... See more keywords