The renal elimination of apixaban: the totality of data relating to the renal clearance of apixaban in patients with impaired renal function: response to Hellfritzsch et al.
Sign Up to like & getrecommendations! Published in 2017 at "Pharmacoepidemiology and Drug Safety"
DOI: 10.1002/pds.4163
Abstract: Hellfritzsch et al. discuss an apparent lack of consistency in reporting of renal elimination data among novel oral anticoagulant drugs: with a focus on apixaban.1 We would like to provide the totality of data that… read more here.
Keywords: apixaban; renal clearance; clearance; renal impairment ... See more keywords
Investigation of pharmacokinetic and clinical outcomes of various meropenem regimens in patients with ventilator-associated pneumonia and augmented renal clearance.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of clinical pharmacology"
DOI: 10.1007/s00228-022-03291-5
Abstract: INTRODUCTION Augmented renal clearance (ARC) defined as creatinine clearance (Clcr) above 130 mL/min/1.73m2 may lead to suboptimal antibacterial treatment. The aim of this study was to determine a strategy for meropenem administration to achieve both pharmacodynamic-pharmacokinetic… read more here.
Keywords: group; clearance; renal clearance; clinical outcomes ... See more keywords
Augmented renal clearance: a common condition in critically ill children
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric Nephrology"
DOI: 10.1007/s00467-019-04205-x
Abstract: BackgroundAugmented renal clearance (ARC), an increase in kidney function with enhanced elimination of circulating solute, has been increasingly recognized in critically ill adults. In a pediatric intensive care setting, data are scarce. The primary objective… read more here.
Keywords: ill children; critically ill; renal clearance; schwartz formula ... See more keywords
Population Pharmacokinetics of Levetiracetam in Patients with Traumatic Brain Injury and Subarachnoid Hemorrhage Exhibiting Augmented Renal Clearance
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DOI: 10.1007/s40262-020-00979-8
Abstract: Background and Objective Patients with severe trauma exhibit augmented renal clearance, which can alter the dosing requirement of renally eliminated drugs. This study aimed to develop a population pharmacokinetic model for levetiracetam in patients with… read more here.
Keywords: traumatic brain; subarachnoid hemorrhage; renal clearance; clearance ... See more keywords
Pharmacokinetics and Pharmacodynamics of Ceftolozane/Tazobactam in Critically Ill Patients With Augmented Renal Clearance.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2021.106299
Abstract: OBJECTIVE To determine whether established ceftolozane/tazobactam (C/T) dosing is adequate among patients with augmented renal clearance (ARC) and bacterial infection. METHODS ARC (creatinine clearance [CrCl] ≥130 mL/min) was confirmed by directly measured CrCl in 11… read more here.
Keywords: ceftolozane tazobactam; renal clearance; clearance; patients augmented ... See more keywords
Renally Excretable Silver Telluride Nanoparticles as Contrast Agents for X-ray Imaging.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c06190
Abstract: The use of nanoparticles in the biomedical field has gained much attention due to their applications in biomedical imaging, drug delivery, and therapeutics. Silver telluride nanoparticles (Ag2Te NPs) have been recently shown to be highly… read more here.
Keywords: contrast agents; renally excretable; silver telluride; telluride nanoparticles ... See more keywords
In silico models to predict tubular secretion or reabsorption clearance pathway using physicochemical properties and structural characteristics
Sign Up to like & getrecommendations! Published in 2022 at "Xenobiotica"
DOI: 10.1080/00498254.2022.2076632
Abstract: Abstract Renal clearance is one of the main pathways for a drug to be cleared from plasma. The aim of this study is to develop in-silico models to find out the relationship between the type… read more here.
Keywords: clearance; reabsorption; tubular secretion; silico models ... See more keywords
1364: AMINOGLYCOSIDE CLEARANCE MAY BE USEFUL TO DETECT AUGMENTED RENAL CLEARANCE IN THE CRITICALLY ILL
Sign Up to like & getrecommendations! Published in 2018 at "Critical Care Medicine"
DOI: 10.1097/01.ccm.0000529367.48490.84
Abstract: Critical Care Medicine • Volume 46 • Number 1 (Supplement) www.ccmjournal.org Learning Objectives: Augmented renal clearance (ARC) is a syndrome characterized by enhanced glomerular filtration of solutes and medications in the nephron. ARC has been… read more here.
Keywords: medicine; arctic score; critically ill; renal clearance ... See more keywords
Identifying augmented renal clearance in trauma patients: Validation of the Augmented Renal Clearance in Trauma Intensive Care scoring system
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Trauma and Acute Care Surgery"
DOI: 10.1097/ta.0000000000001387
Abstract: BACKGROUND Augmented renal clearance (ARC) is common in trauma patients and associated with subtherapeutic antimicrobial concentrations. This study reported the incidence of ARC, identified ARC risk factors, and described a model to predict ARC (i.e.,… read more here.
Keywords: system; trauma; trauma patients; renal clearance ... See more keywords
Validation of the Augmented Renal Clearance in Trauma Intensive Care scoring system for augmented renal clearance prediction in a trauma subgroup of a mixed ICU population
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Pharmacy and Therapeutics"
DOI: 10.1111/jcpt.13695
Abstract: Augmented renal clearance is prevalent in trauma patients and leads to subtherapeutic levels of renally eliminated medications with potentially unfavourable clinical outcomes. The Augmented Renal Clearance of Trauma in Intensive Care (ARCTIC) score has been… read more here.
Keywords: augmented renal; intensive care; trauma; renal clearance ... See more keywords
Plasma trough concentration distribution and safety of high‐dose teicoplanin for patients with augmented renal clearance
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Pharmacy and Therapeutics"
DOI: 10.1111/jcpt.13700
Abstract: There are few reports on the distribution of the plasma trough concentration (Cmin) of teicoplanin in patients with augmented renal clearance (ARC) and on the safety of a high‐dose regimen (HD; 800 mg loading dose for… read more here.
Keywords: plasma trough; patients augmented; teicoplanin patients; renal clearance ... See more keywords