The intact nephron hypothesis as a model for renal drug handling
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-018-2572-8
Abstract: PurposeThe intact nephron hypothesis (INH) states that impaired renal function results from a reduction in the number of complete (intact) nephrons. Under this model, renal drug clearance is assumed to be a linear function of… read more here.
Keywords: inh; renal drug; drug; intact nephron ... See more keywords
Interactions between meropenem and renal drug transporters.
Sign Up to like & getrecommendations! Published in 2022 at "Current drug metabolism"
DOI: 10.2174/1389200223666220428081109
Abstract: BACKGROUND Meropenem is a carbapenem antibiotic and commonly used with other antibiotics for the treatment of bacterial infections. It is primarily eliminated renally by glomerular filtration and renal tubular secretion. OBJECTIVE To evaluate the roles… read more here.
Keywords: inhibition; drug transporters; meropenem renal; interactions meropenem ... See more keywords